Name: WRNexo Antibody
Brand: CUSABIO
SKU: CSB-PA893266XA01DLU

Product Details

Full Product Name	Rabbit anti-Drosophila melanogaster (Fruit fly) WRNexo Polyclonal antibody
Uniprot No.	Q9VE86
Target Names	WRNexo
Alternative Names	WRNexo antibody; CG7670 antibody; Werner Syndrome-like exonuclease antibody; DmWRNexo antibody; EC 3.1.11.- antibody; 3'-5' exonuclease antibody
Raised in	Rabbit
Species Reactivity	Drosophila melanogaster (Fruit fly)
Immunogen	Recombinant Drosophila melanogaster (Fruit fly) WRNexo protein
Immunogen Species	Drosophila melanogaster (Fruit fly)
Conjugate	Non-conjugated
Clonality	Polyclonal
Isotype	IgG
Purification Method	Protein A/G
Concentration	It differs from different batches. Please contact us to confirm it.
Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form	Liquid
Tested Applications	ELISA, WB (ensure identification of antigen)
Protocols	ELISA Protocol
Troubleshooting and FAQs	Antibody FAQs
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables	① 200ug * antigen (positive control); ② 1ml * Pre-immune serum (negative control);
Quality Guarantee	① Antibody purity can be guaranteed above 90% by SDS-PAGE detection; ② ELISA titer can be guaranteed 1: 64,000; ③ WB validation with antigen can be guaranteed positive;
Lead Time	Made-to-order (14-16 weeks)

Target Background

Function (From Uniprot)	Essential for the formation of DNA replication focal centers. Has an important role in maintaining genome stability. Has exonuclease activity on both single-stranded and duplex templates bearing overhangs, but not blunt ended duplex DNA, and cleaves in a 3'-5' direction.
Gene References into Functions	WRNexo is important for recovery following both endogenous and exogenous replication stress; the critical role of WRNexo during replication stress does not depend on exonuclease activity PMID: 24709634 The Drosophila WRN ortholog demonstrates an important role for WRN exonuclease in maintaining genome stability. PMID: 18346216 DmWRNexo is a 3'-5' exonuclease: phenotypic and biochemical characterization of mutants of the Drosophila orthologue of human WRN exonuclease. PMID: 18956248
Subcellular Location	Nucleus.
Protein Families	WRNexo family
Database Links	KEGG: dme:Dmel_CG7670 STRING: 7227.FBpp0291513 UniGene: Dm.4528

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WRNexo Antibody

Code	CSB-PA893266XA01DLU
Size	Enquire
Have Questions?	Leave a Message or Start an on-line Chat