Recombinant Drosophila melanogaster Werner Syndrome-like exonuclease(WRNexo)

Code CSB-YP893266DLU
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Source Yeast
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Code CSB-EP893266DLU
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Source E.coli
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Code CSB-EP893266DLU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP893266DLU
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Source Baculovirus
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Code CSB-MP893266DLU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names WRNexo
Uniprot No. Q9VE86
Alternative Names WRNexo; CG7670; Werner Syndrome-like exonuclease; DmWRNexo; EC 3.1.11.-; 3'-5' exonuclease
Species Drosophila melanogaster (Fruit fly)
Expression Region 1-353
Target Protein Sequence MEKYLTKMPI KSKANEVPKE EAGVKKETPK VARKATKKDT PKELKDKENA GDDNTPKQTK GRPGRPAAKR KNLDTPDVTE KLAMEEENPP KRRSSRLTRS TRSMAEDGSP SPEKEKPEKL PFIKYKGAIK YFTESQDIAA SADDVLQWVE KQKDEVVPMA FDMEWPFSFQ TGPGKSAVIQ ICVDEKCCYI YQLTNVKKLP AALVALINHP KVRLHGVNIK NDFRKLARDF PEVTAEPLIE KCVDLGLWCN EVCETGGRWS LERLTNFIAK KAMDKSKKVR MSKWHVIPLD ENQLMYAAID VYIGQVIYRE LERREKVKIK NEEEFKEKNG DAAFKAMKAL GETFLTKINE VTL
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Essential for the formation of DNA replication focal centers. Has an important role in maintaining genome stability. Has exonuclease activity on both single-stranded and duplex templates bearing overhangs, but not blunt ended duplex DNA, and cleaves in a 3'-5' direction.
Gene References into Functions
  1. WRNexo is important for recovery following both endogenous and exogenous replication stress; the critical role of WRNexo during replication stress does not depend on exonuclease activity PMID: 24709634
  2. The Drosophila WRN ortholog demonstrates an important role for WRN exonuclease in maintaining genome stability. PMID: 18346216
  3. DmWRNexo is a 3'-5' exonuclease: phenotypic and biochemical characterization of mutants of the Drosophila orthologue of human WRN exonuclease. PMID: 18956248
Subcellular Location Nucleus.
Protein Families WRNexo family
Database Links

KEGG: dme:Dmel_CG7670

STRING: 7227.FBpp0291513

UniGene: Dm.4528

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