yap1 Antibody

1. The authors show that the Hippo pathway transcriptional coactivators Yap1 and Wwtr1 are specifically localized to the presumptive epidermis and notochord, and play a critical and unexpected role in posterior body extension by regulating Fibronectin assembly underneath the presumptive epidermis and surrounding the notochord. PMID: 29283341
2. YAP activation is a hallmark of malignant brain tumours. PMID: 27935819
3. that Yap1 entered the nucleus and promoted transcription in response to blood flow. PMID: 28350986
4. that Yap1 integrates the anabolic demands of tissue growth during development and tumorigenesis by reprogramming nitrogen metabolism to stimulate nucleotide biosynthesis PMID: 27428308
5. data reveals that Yap is required for pronephric duct integrity, maintenance of baso-lateral cell polarity, and ciliogenesis during zebrafish kidney development PMID: 26157348
6. Yap/Taz-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish. PMID: 26209646
7. Yap is essential for fin regeneration and that its function is dependent on mechanical tension, conferred by a balancing act of cell density and cytoskeleton activity. PMID: 26209644
8. When transcriptional coactivators Yap and Taz were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline. PMID: 24560909
9. Yap coordinately regulates cell proliferation and apoptosis and is required for dorsoventral axis formation, gastrulation, cardiogenesis, hematopoiesis, and somitogenesis. PMID: 23494967
10. zebrafish yap is required for the development of the brain, eyes, and neural crest during embryogenesis. PMID: 19393221

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KEGG: dre:561411

STRING: 7955.ENSDARP00000089684

UniGene: Dr.119226