YAP1, yes-associated protein 1, alias Yes1 Associated Transcriptional Regulator, YAP652, YAP-12, Yes-Associated Protein YAP65 Homolog, Transcriptional Coactivator YAP1, Yes Associated Protein 123, Protein Yorkie Homolog, Yes-Associated Protein 1, 65kDa, etc . It is a transcriptional co-activator whose activity is controlled by the Hippo signaling pathway and plays an important role in normal tissue homeostasis and regeneration, as well as in cancer development, invasion, metastasis, and resistance to therapy.The mechanism of action of YAP1 is mainly to affect cell proliferation and apoptosis by correlating with kinase cascades in the Hippo signaling pathway. When the Hippo signaling pathway is activated, YAP1 is phosphorylated by LATS1/2 kinases, leading to its segregation in the cytoplasm and proteasomal degradation. And when the Hippo signaling pathway is turned off, YAP1 is dephosphorylated and translocated to the nucleus, where it binds to transcription factors, such as members of the TEAD family, and activates the expression of downstream genes, thereby regulating cell growth, metabolism, proliferation, migration, invasion, or death . In addition, YAP1 is also involved in the regulation of tissue tension and 3D tissue morphology, and plays a role in regulating the formation of cortical actin networks.
YAP1 has a wide range of biological significance, which is not only involved in the regulation of tissue growth and organ size, but is also closely related to the development of a variety of diseases.Abnormal expression or dysfunction of YAP1 has been associated with tumorigenesis, invasiveness, metastasis, and resistance to treatment. that is a potential target in cancer therapy. In addition, YAP1 is involved in the regulation of important biological processes such as immune response, cell contact response, cell proliferation and apoptosis.
Recombinant Human Transcriptional coactivator YAP1 (YAP1) (CSB-YP026244HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Validated Data
Western Blot analysis of HepG2 cells using YAP Polyclonal Antibody
Western Blot analysis of HepG2 RAT-MUSCLE cells using YAP Polyclonal Antibody
The following YAP1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
YAP1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA026244GA01HU | YAP1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA593016 | Phospho-YAP1 (Ser127) Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA913770 | YAP1 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA000707 | Phospho-YAP1 (S127) Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
CSB-PA004537 | YAP1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA004538 | YAP1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-RA026244A127phHU | Phospho-YAP1 (S127) Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
CSB-PA026244ZA01HU | YAP1 Antibody | Homo sapiens | ELISA, WB (ensure identification of antigen) |
CSB-PA026244LA01HU | YAP1 Antibody | Human | ELISA, IHC, IF |
CSB-PA026244LB01HU | YAP1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA026244LC01HU | YAP1 Antibody, FITC conjugated | Human | |
CSB-PA026244LD01HU | YAP1 Antibody, Biotin conjugated | Human | ELISA |
CSB-PA026244LA11HU | YAP1 Antibody | Human | ELISA, WB, IF |
CSB-PA026244LB11HU | YAP1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA026244LC11HU | YAP1 Antibody, FITC conjugated | Human | |
CSB-PA026244LD11HU | YAP1 Antibody, Biotin conjugated | Human | ELISA |
YAP1 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA323980XA01SVG | YAP1 Antibody | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | ELISA, WB (ensure identification of antigen) |
YAP1 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA914846XA01DIL | yap1 Antibody | Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
YAP1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP026244HU | Recombinant Human Transcriptional coactivator YAP1 (YAP1) | Yeast |
CSB-EP026244HU | Recombinant Human Transcriptional coactivator YAP1 (YAP1) | E.coli |
CSB-BP026244HU CSB-MP026244HU CSB-EP026244HU-B |
Recombinant Human Transcriptional coactivator YAP1 (YAP1) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP026244HUc7 | Recombinant Human Transcriptional coactivator YAP1 (YAP1) | E.coli |
CSB-EP026244HUd7 | Recombinant Human Transcriptional coactivator YAP1 (YAP1) | E.coli |
YAP1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP026244MO CSB-EP026244MO CSB-BP026244MO CSB-MP026244MO CSB-EP026244MO-B |
Recombinant Mouse Yorkie homolog (Yap1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
YAP1 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP026244CH CSB-EP026244CH CSB-BP026244CH CSB-MP026244CH CSB-EP026244CH-B |
Recombinant Chicken Yorkie homolog (YAP1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
YAP1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Code | Product Name | Source |
---|---|---|
CSB-YP323980SVG CSB-EP323980SVG CSB-BP323980SVG CSB-MP323980SVG CSB-EP323980SVG-B |
Recombinant Saccharomyces cerevisiae AP-1-like transcription factor YAP1 (YAP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
YAP1 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Code | Product Name | Source |
---|---|---|
CSB-YP345945KBK CSB-EP345945KBK CSB-BP345945KBK CSB-MP345945KBK CSB-EP345945KBK-B |
Recombinant Kluyveromyces lactis AP-1-like transcription factor (YAP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
YAP1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP645005RA CSB-EP645005RA CSB-BP645005RA CSB-MP645005RA CSB-EP645005RA-B |
Recombinant Rat Yorkie homolog (Yap1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |