inlA Antibody

Code CSB-PA338647ZA01LPY
Size
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) inlA Polyclonal antibody
Uniprot No.
Target Names
inlA
Alternative Names
Internalin-A, inlA
Raised in
Rabbit
Species Reactivity
Listeria monocytogenes serovar 1/2a
Immunogen
Recombinant Listeria monocytogenes serovar 1/2a inlA protein
Immunogen Species
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Conjugate
Non-conjugate
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Mediates the entry of L.monocytogenes into host intestinal epithelial cells; transformation with inlA alone allows L.innocua (a non-invasive species) to be taken up by host cells. Binds to human receptor cadherin-1 (E-cadherin, CDH1); the chicken homolog of cadherin-1 but not cadherin-2 function as receptors. Mouse cadherin-1 is not a receptor, however mutating a single surface-exposed residue (Glu-172 to Pro in mouse) allows cadherin-1 to act as a receptor for InlA.
Gene References into Functions
  1. Deletion of either one or both proteins leads to a similarly decreased invasion, suggesting an interdependent function of InlA and InlB during invasion of choroid plexus epithelial cells. PMID: 23376167
  2. About 40% of Listeria monocytogenes isolates (three subtypes) were found to potentially present attenuated virulence because of the presence of mutations in the prfA and inlA genes PMID: 23317868
  3. A novel single amino acid change in inlA enhanced virulence by the oral route in the murine model. PMID: 21144051
  4. Listeria monocytogenes internalin interacts with E-cadherin [review] PMID: 20066101
  5. L. monocytogenes subtypes are common among U.S. food isolates but rare among human listeriosis isolates carry inlA mutations. PMID: 16332872
  6. Differential expression levels of inlA and inlB possibly play a role in the virulence capacities of Listeria monocytogenes strains. PMID: 16751490
  7. Sequence analyses of inlA among L. monocytogenes isolated from ready-to-eat seafood revealed that only one out of 59 isolates had a nonsense-mutated inlA which indicated that these strains could be fully virulent based on the size of this protein. PMID: 17566579
  8. the essential and interdependent roles of InlA and InlB in fetoplacental listeriosis PMID: 18806773
  9. analysis of the internalin multigene family in Listeria PMID: 18840511
  10. truncated and/or proteolytically cleaved InlA are likely involved in the biofilm enhancement. PMID: 19309566

Show More

Hide All

Subcellular Location
Secreted, cell wall; Peptidoglycan-anchor. Secreted.
Database Links

KEGG: lmo:lmo0433

STRING: 169963.lmo0433

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1