vpr Antibody

Datasheet
Code CSB-PA314796ZA01HLP
Uniprot No. P0C1P2
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Human immunodeficiency virus type 1 group M subtype K Protein Vpr (vpr) (1-96AA)
Raised in Rabbit
Species Reactivity Human immunodeficiency virus type 1 group M subtype K
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Protein Vpr (R ORF protein) (Viral protein R), vpr
Immunogen Species Human immunodeficiency virus type 1 group M subtype K (isolate 96CM-MP535) (HIV-1)
Gene Names vpr
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest. Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 E3 ligase complex by direct interaction with host VPRPB/DCAF-1. Cell cycle arrest reportedly occurs within hours of infection and is not blocked by antiviral agents, suggesting that it is initiated by the VPR carried into the virion. Additionally, VPR induces apoptosis in a cell cycle dependent manner suggesting that these two effects are mechanistically linked. Detected in the serum and cerebrospinal fluid of AIDS patient, VPR may also induce cell death to bystander cells.
Subcellular Location Virion, Host nucleus, Host extracellular space
Protein Families HIV-1 VPR protein family

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