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Code | CSB-EP314796HLP |
Size | US$306 |
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The expression region of this recombinant Human immunodeficiency virus type 1 vpr covers amino acids 1-96. The calculated molecular weight for this vpr protein is 18.8 kDa. This vpr recombinant protein is manufactured in e.coli. The N-terminal 10xHis tag and C-terminal Myc tag was smoothly integrated into the coding gene of vpr, which enables a simple process of detecting and purifying the vpr recombinant protein in the following steps.
The human immunodeficiency virus type 1 (HIV-1) group M subtype K protein Vpr, or viral protein R, is a regulatory protein encoded by the vpr gene of the HIV-1 genome. Vpr plays a multifaceted role in the viral life cycle and pathogenesis. It is involved in nuclear import of the pre-integration complex, influencing viral transcription, and promoting the G2 cell cycle arrest of host cells, facilitating efficient viral replication. Additionally, Vpr contributes to immune evasion and modulation of host cell apoptosis. The protein's interaction with various host factors underscores its significance in HIV-1 replication and the progression of the infection. Research on HIV-1 Vpr is essential for understanding the molecular mechanisms of viral pathogenesis and can inform the development of targeted antiretroviral therapies.There are currently no reviews for this product.