Human C-C motif chemokine 4(CCL4) ELISA kit

Code CSB-EL004797HU
Size 96T,5×96T,10×96T
Price Request a Quote or Start an on-line Chat
Trial Size 24T ELISA Kit Trial Size (Only USD$150/ kit)
* The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now

Product Details

Alternative Names
MIP 1 beta ELISA Kit; Secreted protein G 26 ELISA Kit; ACT 2 ELISA Kit; ACT-2 ELISA Kit; ACT2 ELISA Kit; AT744.1 ELISA Kit; AT744.2 ELISA Kit; C C motif chemokine 4 ELISA Kit; C C motif chemokine 4 like ELISA Kit; C C motif chemokine ligand 4 like 1 ELISA Kit; C C motif chemokine ligand 4 like 2 ELISA Kit; CC chemokine ligand 4 ELISA Kit; CC chemokine ligand 4L1 ELISA Kit; CC chemokine ligand 4L1d2 ELISA Kit; CC chemokine ligand 4L2 ELISA Kit; CCL4 ELISA Kit; CCL4_HUMAN ELISA Kit; ccl4l 1 ELISA Kit; CCL4L ELISA Kit; CCL4L1 ELISA Kit; Chemokine (C C motif) ligand 4 ELISA Kit; Chemokine (C C motif) ligand 4 like 1 ELISA Kit; Chemokine (C C motif) ligand 4 like 1; telomeric ELISA Kit; Chemokine (C C motif) ligand 4 like 2 ELISA Kit; Chemokine CC Motif Ligand 4 ELISA Kit; G 26 ELISA Kit; G 26 T lymphocyte secreted protein ELISA Kit; G-26 T-lymphocyte-secreted protein ELISA Kit; HC21 ELISA Kit; Immune activation 2 ELISA Kit; LAG 1 ELISA Kit; LAG-1 ELISA Kit; LAG1 ELISA Kit; Lymphocyte activation gene 1 ELISA Kit; Lymphocyte activation gene 1 protein ELISA Kit; Macrophage inflammatory protein 1 beta ELISA Kit; Macrophage inflammatory protein 1-beta ELISA Kit; Macrophage inflammatory protein 1b2 ELISA Kit; MGC104418 ELISA Kit; MGC126025 ELISA Kit; MGC126026 ELISA Kit; MIP-1-beta ELISA Kit; MIP-1-beta(1-69) ELISA Kit; MIP-1-beta(3-69) ELISA Kit; MIP1 beta ELISA Kit; MIP1B ELISA Kit; MIP1B1 ELISA Kit; Monocyte adherence induced protein 5 alpha ELISA Kit; PAT 744 ELISA Kit; Protein H400 ELISA Kit; SCYA2 ELISA Kit; SCYA4 ELISA Kit; SCYA4L ELISA Kit; SCYA4L1 ELISA Kit; SCYA4L2 ELISA Kit; SCYQ4L2 ELISA Kit; Secreted protein G 26 ELISA Kit; Secreted protein G26 ELISA Kit; SIS gamma ELISA Kit; SIS-gamma ELISA Kit; Small inducible cytokine A4 (homologous to mouse Mip 1b) ELISA Kit; Small inducible cytokine A4 ELISA Kit; small inducible cytokine A4-like ELISA Kit; Small-inducible cytokine A4 ELISA Kit; T cell activation protein 2 ELISA Kit; T-cell activation protein 2 ELISA Kit
Abbreviation
CCL4
Uniprot No.
Species
Homo sapiens (Human)
Sample Types
serum, plasma, tissue homogenates
Detection Range
31.2 pg/ml - 2000 pg/ml
Sensitivity
7.8 pg/ml
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Immunology
Assay Principle
quantitative
Measurement
Sandwich
Troubleshooting
and FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx
Description

This Human CCL4 ELISA Kit was designed for the quantitative measurement of Human CCL4 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 31.2 pg/ml - 2000 pg/ml and the sensitivity is 7.8 pg/ml.

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Target Background

Function
(From Uniprot)
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Gene References into Functions
  1. identified 13 ADCC-activated genes. Six gene expression assays including 8 of the 13 genes (CCL3, CCL4/CCL4L1/CCL4L2, CD160, IFNG, NR4A3 and XCL1/XCL2) were analyzed in 127 kidney biopsies PMID: 25449536
  2. PCR results show that lower copy numbers of CCL4L1 are observed in the Caucasian population nd higher copy numbers are observed in the Black population of South Africa. PMID: 24727646
  3. CCL4L1 allele frequency is higher in severe psoriasis, whereas CCL4L2 is more frequent in patients with a milder disease. PMID: 21614014
  4. multiple copies of CCL3L1 and CCL4L1 present in a single diploid genome are the result of segmental duplication at chromosome 17q12 PMID: 15028295
Subcellular Location
Secreted.
Protein Families
Intercrine beta (chemokine CC) family
Database Links

HGNC: 10630

OMIM: 182284

KEGG: hsa:388372

STRING: 9606.ENSP00000250151

UniGene: Hs.449862

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