CCL4 Antibody, Biotin conjugated

Code CSB-PA05949D0Rb
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CCL4 Polyclonal antibody
Uniprot No.
Target Names
CCL4
Alternative Names
MIP 1 beta antibody; Secreted protein G 26 antibody; ACT 2 antibody; ACT-2 antibody; ACT2 antibody; AT744.1 antibody; AT744.2 antibody; C C motif chemokine 4 antibody; C C motif chemokine 4 like antibody; C C motif chemokine ligand 4 like 1 antibody; C C motif chemokine ligand 4 like 2 antibody; CC chemokine ligand 4 antibody; CC chemokine ligand 4L1 antibody; CC chemokine ligand 4L1d2 antibody; CC chemokine ligand 4L2 antibody; CCL4 antibody; CCL4_HUMAN antibody; ccl4l 1 antibody; CCL4L antibody; CCL4L1 antibody; Chemokine (C C motif) ligand 4 antibody; Chemokine (C C motif) ligand 4 like 1 antibody; Chemokine (C C motif) ligand 4 like 1; telomeric antibody; Chemokine (C C motif) ligand 4 like 2 antibody; Chemokine CC Motif Ligand 4 antibody; G 26 antibody; G 26 T lymphocyte secreted protein antibody; G-26 T-lymphocyte-secreted protein antibody; HC21 antibody; Immune activation 2 antibody; LAG 1 antibody; LAG-1 antibody; LAG1 antibody; Lymphocyte activation gene 1 antibody; Lymphocyte activation gene 1 protein antibody; Macrophage inflammatory protein 1 beta antibody; Macrophage inflammatory protein 1-beta antibody; Macrophage inflammatory protein 1b2 antibody; MGC104418 antibody; MGC126025 antibody; MGC126026 antibody; MIP-1-beta antibody; MIP-1-beta(1-69) antibody; MIP-1-beta(3-69) antibody; MIP1 beta antibody; MIP1B antibody; MIP1B1 antibody; Monocyte adherence induced protein 5 alpha antibody; PAT 744 antibody; Protein H400 antibody; SCYA2 antibody; SCYA4 antibody; SCYA4L antibody; SCYA4L1 antibody; SCYA4L2 antibody; SCYQ4L2 antibody; Secreted protein G 26 antibody; Secreted protein G26 antibody; SIS gamma antibody; SIS-gamma antibody; Small inducible cytokine A4 (homologous to mouse Mip 1b) antibody; Small inducible cytokine A4 antibody; small inducible cytokine A4-like antibody; Small-inducible cytokine A4 antibody; T cell activation protein 2 antibody; T-cell activation protein 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human C-C motif chemokine 4 protein (24-84AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Gene References into Functions
  1. identified 13 ADCC-activated genes. Six gene expression assays including 8 of the 13 genes (CCL3, CCL4/CCL4L1/CCL4L2, CD160, IFNG, NR4A3 and XCL1/XCL2) were analyzed in 127 kidney biopsies PMID: 25449536
  2. PCR results show that lower copy numbers of CCL4L1 are observed in the Caucasian population nd higher copy numbers are observed in the Black population of South Africa. PMID: 24727646
  3. CCL4L1 allele frequency is higher in severe psoriasis, whereas CCL4L2 is more frequent in patients with a milder disease. PMID: 21614014
  4. multiple copies of CCL3L1 and CCL4L1 present in a single diploid genome are the result of segmental duplication at chromosome 17q12 PMID: 15028295
Subcellular Location
Secreted.
Protein Families
Intercrine beta (chemokine CC) family
Database Links

HGNC: 10630

OMIM: 182284

KEGG: hsa:388372

STRING: 9606.ENSP00000250151

UniGene: Hs.449862

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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