Human Cardiotrophin-like cytokine factor 1(CLCF1) ELISA kit

Code CSB-EL005479HU
Size 96T,5×96T,10×96T
Trial Size 24T ELISA kits trial application
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Product Details

Target Name cardiotrophin-like cytokine factor 1
Alternative Names B cell stimulating factor 3 ELISA Kit; B-cell-stimulating factor 3 ELISA Kit; BSF 3 ELISA Kit; BSF-3 ELISA Kit; BSF3 ELISA Kit; Cardiotrophin like cytokine ELISA Kit; Cardiotrophin like cytokine factor 1 ELISA Kit; Cardiotrophin-like cytokine factor 1 ELISA Kit; CISS 2 ELISA Kit; CISS2 ELISA Kit; CLC ELISA Kit; CLCF 1 ELISA Kit; Clcf1 ELISA Kit; CLCF1_HUMAN ELISA Kit; Cold induced sweating syndrome 2 ELISA Kit; CRLF 1 associated cytokine like factor 1 ELISA Kit; CRLF1 associated cytokine like factor 1 ELISA Kit; Neurotrophin 1 ELISA Kit; Neurotrophin 1/B cell stimulating factor 3 ELISA Kit; Neurotrophin1 ELISA Kit; NNT 1 ELISA Kit; NNT-1 ELISA Kit; Novel neurotrophin 1 ELISA Kit; Novel neurotrophin-1 ELISA Kit; NR 6 ELISA Kit; NR6 ELISA Kit
Abbreviation CLCF1
Uniprot No. Q9UBD9
Species Homo sapiens (Human)
Sample Types serum, plasma, cell culture supernates, tissue homogenates
Detection Range 0.312 ng/mL-20 ng/mL
Sensitivity 0.078 ng/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Others
Assay Principle quantitative
Measurement Sandwich
and FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 7-14 working days

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Target Background

(From Uniprot)
Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor.
Gene References into Functions
  1. CLF-1, based on its binding site for CLC and on two additional and independent sites for CNTFRalpha and sorLA, is a key player in CLC and CNTFRalpha signaling and turnover. PMID: 26858303
  2. Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders. PMID: 26198769
  3. albuminuria in focal segmental glomerulosclerosis is related to qualitative or quantitative changes in the CLCF1-CRLF1 complex. PMID: 25843671
  4. activation of the Jak-STAT cascade is essential for corticotroph NNT-1/BSF-3 signaling. PMID: 12639901
  5. Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC and CNTFRalpha. PMID: 16782820
  6. Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain PMID: 18728012

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Involvement in disease Cold-induced sweating syndrome 2 (CISS2)
Subcellular Location Secreted
Protein Families IL-6 superfamily
Tissue Specificity Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.
Database Links

HGNC: 17412

OMIM: 607672

KEGG: hsa:23529

STRING: 9606.ENSP00000309338

UniGene: Hs.502977


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