Human Cardiotrophin-like cytokine factor 1(CLCF1) ELISA kit

Code CSB-EL005479HU
Size 96T,5×96T,10×96T
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Product Details

Target Name
cardiotrophin-like cytokine factor 1
Alternative Names
B cell stimulating factor 3 ELISA Kit; B-cell-stimulating factor 3 ELISA Kit; BSF 3 ELISA Kit; BSF-3 ELISA Kit; BSF3 ELISA Kit; Cardiotrophin like cytokine ELISA Kit; Cardiotrophin like cytokine factor 1 ELISA Kit; Cardiotrophin-like cytokine factor 1 ELISA Kit; CISS 2 ELISA Kit; CISS2 ELISA Kit; CLC ELISA Kit; CLCF 1 ELISA Kit; Clcf1 ELISA Kit; CLCF1_HUMAN ELISA Kit; Cold induced sweating syndrome 2 ELISA Kit; CRLF 1 associated cytokine like factor 1 ELISA Kit; CRLF1 associated cytokine like factor 1 ELISA Kit; Neurotrophin 1 ELISA Kit; Neurotrophin 1/B cell stimulating factor 3 ELISA Kit; Neurotrophin1 ELISA Kit; NNT 1 ELISA Kit; NNT-1 ELISA Kit; Novel neurotrophin 1 ELISA Kit; Novel neurotrophin-1 ELISA Kit; NR 6 ELISA Kit; NR6 ELISA Kit
Abbreviation
CLCF1
Uniprot No.
Species
Homo sapiens (Human)
Sample Types
serum, plasma, cell culture supernates, tissue homogenates
Detection Range
0.312 ng/mL-20 ng/mL
Sensitivity
0.078 ng/mL
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Others
Assay Principle
quantitative
Measurement
Sandwich
Troubleshooting
and FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx
Description

This Human CLCF1 ELISA Kit was designed for the quantitative measurement of Human CLCF1 protein in serum, plasma, cell culture supernates, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 0.312 ng/mL-20 ng/mL and the sensitivity is 0.078 ng/mL.

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Target Background

Function
(From Uniprot)
In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor.
Gene References into Functions
  1. CLF-1, based on its binding site for CLC and on two additional and independent sites for CNTFRalpha and sorLA, is a key player in CLC and CNTFRalpha signaling and turnover. PMID: 26858303
  2. Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders. PMID: 26198769
  3. albuminuria in focal segmental glomerulosclerosis is related to qualitative or quantitative changes in the CLCF1-CRLF1 complex. PMID: 25843671
  4. activation of the Jak-STAT cascade is essential for corticotroph NNT-1/BSF-3 signaling. PMID: 12639901
  5. Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC and CNTFRalpha. PMID: 16782820
  6. Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain PMID: 18728012

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Involvement in disease
Cold-induced sweating syndrome 2 (CISS2)
Subcellular Location
Secreted.
Protein Families
IL-6 superfamily
Tissue Specificity
Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.
Database Links

HGNC: 17412

OMIM: 607672

KEGG: hsa:23529

STRING: 9606.ENSP00000309338

UniGene: Hs.502977

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