CLCF1 Antibody

Datasheet

Code	CSB-PA906951LA01HU
Size	US$166
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Image	IHC image of CSB-PA906951LA01HU diluted at 1:200 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CLCF1 Polyclonal antibody

Uniprot No.

Q9UBD9

Target Names

CLCF1

Alternative Names

B cell stimulating factor 3 antibody; B-cell-stimulating factor 3 antibody; BSF 3 antibody; BSF-3 antibody; BSF3 antibody; Cardiotrophin like cytokine antibody; Cardiotrophin like cytokine factor 1 antibody; Cardiotrophin-like cytokine factor 1 antibody; CISS 2 antibody; CISS2 antibody; CLC antibody; CLCF 1 antibody; Clcf1 antibody; CLCF1_HUMAN antibody; Cold induced sweating syndrome 2 antibody; CRLF 1 associated cytokine like factor 1 antibody; CRLF1 associated cytokine like factor 1 antibody; Neurotrophin 1 antibody; Neurotrophin 1/B cell stimulating factor 3 antibody; Neurotrophin1 antibody; NNT 1 antibody; NNT-1 antibody; Novel neurotrophin 1 antibody; Novel neurotrophin-1 antibody; NR 6 antibody; NR6 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cardiotrophin-like cytokine factor 1 protein (28-178AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CLCF1 Antibody (Product code: CSB-PA906951LA01HU) is Non-conjugated. For CLCF1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA906951LB01HU	CLCF1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA906951LC01HU	CLCF1 Antibody, FITC conjugated
Biotin	CSB-PA906951LD01HU	CLCF1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor.

Gene References into Functions

CLF-1, based on its binding site for CLC and on two additional and independent sites for CNTFRalpha and sorLA, is a key player in CLC and CNTFRalpha signaling and turnover. PMID: 26858303
Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders. PMID: 26198769
albuminuria in focal segmental glomerulosclerosis is related to qualitative or quantitative changes in the CLCF1-CRLF1 complex. PMID: 25843671
activation of the Jak-STAT cascade is essential for corticotroph NNT-1/BSF-3 signaling. PMID: 12639901
Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC and CNTFRalpha. PMID: 16782820
Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain PMID: 18728012

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Involvement in disease

Cold-induced sweating syndrome 2 (CISS2)

Subcellular Location

Secreted.

Protein Families

IL-6 superfamily

Tissue Specificity

Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.

Database Links

HGNC: 17412

OMIM: 607672

KEGG: hsa:23529

STRING: 9606.ENSP00000309338

UniGene: Hs.502977

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Service

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Protein Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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