CLCF1 Antibody

Code CSB-PA906951LA01HU
Size US$166
  • IHC image of CSB-PA906951LA01HU diluted at 1:200 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CLCF1 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
B cell stimulating factor 3 antibody; B-cell-stimulating factor 3 antibody; BSF 3 antibody; BSF-3 antibody; BSF3 antibody; Cardiotrophin like cytokine antibody; Cardiotrophin like cytokine factor 1 antibody; Cardiotrophin-like cytokine factor 1 antibody; CISS 2 antibody; CISS2 antibody; CLC antibody; CLCF 1 antibody; Clcf1 antibody; CLCF1_HUMAN antibody; Cold induced sweating syndrome 2 antibody; CRLF 1 associated cytokine like factor 1 antibody; CRLF1 associated cytokine like factor 1 antibody; Neurotrophin 1 antibody; Neurotrophin 1/B cell stimulating factor 3 antibody; Neurotrophin1 antibody; NNT 1 antibody; NNT-1 antibody; Novel neurotrophin 1 antibody; Novel neurotrophin-1 antibody; NR 6 antibody; NR6 antibody
Raised in
Species Reactivity
Recombinant Human Cardiotrophin-like cytokine factor 1 protein (28-178AA)
Immunogen Species
Homo sapiens (Human)

The CLCF1 Antibody (Product code: CSB-PA906951LA01HU) is Non-conjugated. For CLCF1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA906951LB01HU CLCF1 Antibody, HRP conjugated ELISA
FITC CSB-PA906951LC01HU CLCF1 Antibody, FITC conjugated
Biotin CSB-PA906951LD01HU CLCF1 Antibody, Biotin conjugated ELISA
Purification Method
>95%, Protein G purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor.
Gene References into Functions
  1. CLF-1, based on its binding site for CLC and on two additional and independent sites for CNTFRalpha and sorLA, is a key player in CLC and CNTFRalpha signaling and turnover. PMID: 26858303
  2. Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders. PMID: 26198769
  3. albuminuria in focal segmental glomerulosclerosis is related to qualitative or quantitative changes in the CLCF1-CRLF1 complex. PMID: 25843671
  4. activation of the Jak-STAT cascade is essential for corticotroph NNT-1/BSF-3 signaling. PMID: 12639901
  5. Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC and CNTFRalpha. PMID: 16782820
  6. Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain PMID: 18728012

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Involvement in disease
Cold-induced sweating syndrome 2 (CISS2)
Subcellular Location
Protein Families
IL-6 superfamily
Tissue Specificity
Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.
Database Links

HGNC: 17412

OMIM: 607672

KEGG: hsa:23529

STRING: 9606.ENSP00000309338

UniGene: Hs.502977

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