Code | CSB-E04680h |
Size | 96T,5×96T,10×96T |
Price | Request a Quote or Start an on-line Chat |
Trial Size |
24T ELISA Kit Trial Size (Only USD$150/ kit) * The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now |
The product CSB-E04680h is a sandwich ELISA kit developed to measure levels of human matrix metalloproteinase 8 (MMP8) in serum, plasma, or tissue homogenates. The enzyme-substrate chromogenic reaction is also used to amplify the signal and quantify the levels of the analyte through the intensity of the colored product. The color intensity positively correlates with the amount of MMP8 bound in the initial step.
MMP8 is responsible for degrading triple-helical type I collagen and numerous extracellular matrix (ECM) and non-ECM substrates. It is released from polymorphonuclear neutrophils (PMN) when neutrophils are activated by proinflammatory mediators or damage-associated molecular patterns (DAMPs). MMP8 thus plays an essential part in mediating inflammation. Expression of MMP8 has increased in gingivitis as well as periodontitis. And MMP8 has been shown to suppress neuroinflammation and inflammation in osteoarthritis. MMP8 plays a crucial role in stem cell migration into atherosclerotic lesions, and its activation in stem cells promotes lesion development. It also plays a prominent role in angiogenesis.
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