Human Neuronal Pentraxin-1(NPTX-1) ELISA kit

Code CSB-E14336h
Size 96T,5×96T,10×96T
Trial Size 24T ELISA Kit Trial Size (Only USD$150/ kit)
* The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now
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Product Details

Target Name
neuronal pentraxin I
Alternative Names
Neuronal pentraxin I ELISA Kit; Neuronal pentraxin-1 ELISA Kit; NP 1 ELISA Kit; NP-I ELISA Kit; NP1 ELISA Kit; Nptx1 ELISA Kit; NPTX1_HUMAN ELISA Kit
Uniprot No.
Homo sapiens (Human)
Sample Types
serum, plasma
Detection Range
7.8 pg/mL-500 pg/mL
1.95 pg/mL
Assay Time
Sample Volume
Detection Wavelength
450 nm
Research Area
Assay Principle
Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.
To assess the linearity of the assay, samples were spiked with high concentrations of human NPTX-1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
1:1Average %93
Range %89-97
1:2Average %103
Range %96-105
1:4Average %93
Range %89-97
1:8Average %98
Range %94-102
The recovery of human NPTX-1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
Sample TypeAverage % RecoveryRange
Serum (n=5) 9793-101
EDTA plasma (n=4)9286-96
Typical Data
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
5002.642 2.443 2.543 2.395
2501.838 1.737 1.788 1.640
1251.034 1.166 1.100 0.952
62.50.613 0.597 0.605 0.457
31.20.398 0.401 0.400 0.252
15.60.264 0.255 0.260 0.112
7.80.196 0.188 0.192 0.044
00.149 0.147 0.148
and FAQs
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx

This Human NPTX1 ELISA Kit was designed for the quantitative measurement of Human NPTX1 protein in serum, plasma. It is a Sandwich ELISA kit, its detection range is 7.8 pg/mL-500 pg/mL and the sensitivity is 1.95 pg/mL.

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Target Background

(From Uniprot)
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.
Gene References into Functions
  1. NPTX1 is down-regulated in colon cancer. In addition, NPTX1 inhibits the proliferation of colon cancer cells via decreasing cyclin A2 and CDK2. PMID: 29345391
  2. NPTX1 was significantly associated with bipolar disorder. PMID: 25053281
  3. findings suggest that lower NARP mRNA expression contributes to lower excitatory drive onto parvalbumin interneurons in schizophrenia. PMID: 26038830
  4. These results suggest that NPTX1 hypermethylation and consequent mRNA changes might be an important molecular mechanism in lung cancer. PMID: 25646694
  5. Taken together, these results demonstrate that NP1 gene is a target of as hypoxia inducible factor-1 alpha and it regulates NP1 expression by binding to hypoxia responsive elements in its promoter region. PMID: 25498504
  6. Long acting progestin contraceptive-enhanced NPTX1 secretion and reactive oxygen species generation in endometrial stromal cells impair endometrial endothelial cells survival resulting in a loss in vascular integrity. PMID: 25029423
  7. NPTX1 binds and inhibits TDGF1, and reduces both Nodal and BMP signaling. PMID: 24529709
  8. Neuronal pentraxin 1 transgene is a key factor for the synapse loss, the neurite damage, and the apoptotic neuronal death evoked by amyloid-beta protein, which regulates NP1 expression. PMID: 17151277
  9. The purpose of the present study was to assess the toxic effect of taipoxin in SCLC-cell lines and to determine if toxicity correlates to NPR and NP1 and NP2 expression levels. PMID: 16115696

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Subcellular Location
Cytoplasmic vesicle, secretory vesicle.
Database Links

HGNC: 7952

OMIM: 602367

KEGG: hsa:4884

STRING: 9606.ENSP00000307549

UniGene: Hs.514556

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