Human lymphotactin,Lptn/LTN ELISA Kit

Code CSB-E08712h
Size 96T,5×96T,10×96T How to order?
Trial Size 24T ELISA kits trial application
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Product Details


This Human XCL1 ELISA Kit was designed for the quantitative measurement of Human XCL1 protein in serum, plasma,tissue homogenates. It is a Sandwich ELISA kit, its detection range is 31.25 pg/mL-2000 pg/mL and the sensitivity is 7.81 pg/mL.

Alternative Names ATAC ELISA Kit; C motif chemokine 1 ELISA Kit; Chemokine (C motif) ligand 1 ELISA Kit; Chemokine C Motif Ligand 1 ELISA Kit; Cytokine SCM-1 ELISA Kit; LPTN ELISA Kit; LTN ELISA Kit; Lymphotactin ELISA Kit; Lymphotaxin ELISA Kit; SCM 1 alpha ELISA Kit; SCM 1 ELISA Kit; SCM 1a ELISA Kit; SCM-1-alpha ELISA Kit; SCM1 ELISA Kit; SCM1A ELISA Kit; SCYC1 ELISA Kit; Single cysteine motif 1a ELISA Kit; Small inducible cytokine C1 ELISA Kit; Small Inducible Cytokine Subfamily C Member 1 ELISA Kit; Small inducible cytokine subfamily C, member 1 (lymphotactin) ELISA Kit; Small-inducible cytokine C1 ELISA Kit; X-C motif chemokine ligand 1 ELISA Kit; XC chemokine ligand 1 ELISA Kit; Xcl1 ELISA Kit; XCL1_HUMAN ELISA Kit
Abbreviation XCL1
Uniprot No. P47992
Species Homo sapiens (Human)
Sample Types serum, plasma,tissue homogenates
Detection Range 0.39 ng/ml - 25 ng/ml
Sensitivity 0.0975 ng/ml
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Immunology
Assay Principle quantitative
Measurement Sandwich
ELISA Data Analysis Watch ELISA data processing video & download Curve Expert if needed
and FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

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Target Background

(From Uniprot)
Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.
Gene References into Functions
  1. higher serum XCL1 levels at diagnosis and their progressive decline throughout chemotherapy could be correlated with higher survival. PMID: 29027574
  2. This study defines a Glycosaminoglycan binding surface on XCL1 dimer that includes residues that are important for HIV-1 inhibition. PMID: 26836755
  3. Electrostatics and Hydrophobic Effects in the Metamorphic Protein Human Lymphotactin PMID: 26134347
  4. XCL1 acts via direct interaction with the external viral envelope glycoprotein, gp120, to block HIV-1 infection PMID: 26085164
  5. analysis of XCL1 and XCL2, members of the C-chemokine subfamily, in the immune system PMID: 25497737
  6. XCL1 displays antimicrobial activity against E. coli and S. aureus. PMID: 12949249
  7. XCL1-mediated inhibition is associated with direct interaction of the chemokine with the HIV-1 envelope. PMID: 24385911
  8. In native annulus fibrosus tissue homeostasis and repair, CXCR3 is evident, whereas XCL1 could not be detected. PMID: 21270681
  9. The expression patterns of XCR1 and XCL1 were conserved in human and mice blood cells, including certain dendritic cell subsets. PMID: 20541533
  10. Data indicated increased expression of XCL1 in CD4+ and CD8+ T cells in Wegener's granulomatosis (WG), and suggest that XCL1 might be a key modulator of T cell recruitment in WG. PMID: 19797511
  11. NMR spectra of human lymphotactin (hLtn), obtained under various solution conditions, have revealed that the protein undergoes a major conformational rearrangement dependent on temperature and salt concentration. PMID: 11889129
  12. lymphotactin, as well as MCP-1, may contribute to leukocyte infiltration and disease progression in IgA nephropathy. PMID: 12053063
  13. Lptn might be a key modulator for T cell trafficking in the pathogenesis of rheumatoid arthritis PMID: 12847680
  14. In humans XCL1 expression is mainly a property of CD8+ T cells; the contribution to its synthesis by different T cell receptor alpha beta-expressing T cell subsets, namely CD4+ lymphocytes, is negligible. PMID: 14568926
  15. lymphotactin utilizes highly specific glycosaminoglycan-binding sites PMID: 14707146
  16. XCL1 activation is positively correlated with HIV-1 Tat expression in human U87.MG astrocytes in vitro. PMID: 14734774
  17. description of a lymphotactin-producing monoclonal T-cell lymphoproliferative disorder with extreme lymphocytopenia and progressive leukoencephalopathy [case report] PMID: 16923584
  18. The monocyte-derived dendritic cells can express Lptn mRNA in a maturation-dependent manner. PMID: 17077010
  19. Elevated serum lymphotactin levels correlate with relatively milder manifestations in diffuse cutaneous systemic sclerosis (dSSc), especially lower severity of lung involvement, suggesting that lymphotactin may play a role in the development of dSSc. PMID: 18322986
  20. functional repertoire and regulation of a single naturally occurring amino acid sequence can be expanded by access to a set of highly dissimilar native-state structures PMID: 18364395
  21. XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma PMID: 18832695
  22. ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein PMID: 18838386

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Subcellular Location Secreted.
Protein Families Intercrine gamma family
Tissue Specificity Highest level in spleen, lower in peripheral leukocytes and very low levels in lung, colon and small intestine.
Database Links

HGNC: 10645

OMIM: 600250

KEGG: hsa:6375

STRING: 9606.ENSP00000356792

UniGene: Hs.458346

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