Mouse CD48 antigen(CD48) ELISA kit

Instructions
Code CSB-EL004941MO
Size 96T,5×96T,10×96T
See More Details 24T ELISA kits trial application
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Product Details

Target Name CD48 molecule
Alternative Names Cd48 ELISA kit; Bcm-1CD48 antigen ELISA kit; BCM1 surface antigen ELISA kit; BLAST-1 ELISA kit; HM48-1 ELISA kit; MRC OX-45 surface antigen ELISA kit; SLAM family member 2 ELISA kit; SLAMF2 ELISA kit; Signaling lymphocytic activation molecule 2 ELISA kit; sgp-60 ELISA kit; CD antigen CD48 ELISA kit
Abbreviation CD48
Uniprot No. P18181
Species Mus musculus (Mouse)
Detection Range Request Information
Sensitivity Request Information
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Immunology
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 7-14 working days

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Target Data

Function Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.
Gene References into Functions
  1. Molecular dynamic simulation explains unbinding and unfolding of CD48-2B4 protein complexes. PMID: 25142868
  2. These data demonstrate the important role of CD48 in SA/exotoxins-eosinophil activating interactions that can take place during allergic responses and indicate CD48 as a novel therapeutic target for allergy and especially of AD. PMID: 25255823
  3. ORMDL3 promotes eosinophil trafficking and activation via regulation of CD18, CD49d, and CD48. PMID: 24056518
  4. Ox-LDL significantly promoted the interaction of natural killer cells and dendritic cells via CD48-2B4 contact-dependent mechanisms. PMID: 21221603
  5. B6-specific background genes modulate the effect of CD48 on lupus nephritis in a recessive manner PMID: 21561736
  6. CD48 plays a vital role as an environmental sensor for regulating hematopoietic stem cells and progenitor cell numbers and inhibiting tumor development PMID: 21576698
  7. CD48 on surrounding NK or non-NK cells serves primarily as a ligand to stimulate 2B4 on the adjacent NK cells in mice PMID: 20647560
  8. CD48 interactions with NK cell receptor 2B4 among neighboring T cells during T cell priming augment CTL lysis of their specific targets. PMID: 12734329
  9. compare the relative contributions of MHC class I and CD48 to NK cell self-tolerance; and CD244 regulates NK cell tolerance to normal cells in vivo; evidence for MHC-independent NK self-recognition in a bone marrow rejection assay PMID: 15870174
  10. Cell surface receptors of the SLAM family, including CD150, CD244, and CD48, were differentially expressed among functionally distinct hematopoietic progenitor cells. PMID: 15989959
  11. Review of recent studies suggests an important role for interactions between 2B4 and CD48 in the course of T cell activation and proliferation PMID: 16081768
  12. T cell-induced experimental colitis is ameliorated only when CD48 is absent from both T cells and antigen-presenting cells. PMID: 16472597
  13. the mechanism of signal transduction by CD244 is to regulate FYN kinase recruitment and/or activity and the outcome of CD48/CD244 interactions is determined by which other receptors are engaged. PMID: 17599905

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Subcellular Location Cell membrane, Lipid-anchor, GPI-anchor
Database Links

KEGG: mmu:12506

STRING: 10090.ENSMUSP00000064241

UniGene: Mm.1738

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