Mouse EGF-like repeat and discoidin I-like domain-containing protein 3(EDIL3) ELISA kit

1. these results indicate a protective role for Del-1 in postoperative peritoneal adhesion formation. PMID: 29684347
2. these data reveal an unrecognised function of endogenous Del-1 as a local inhibitor of ischaemia-induced angiogenesis by restraining LFA-1-dependent homing of pro-angiogenic haematopoietic cells to ischaemic tissues PMID: 28447099
3. Del-1-induced HSC proliferation and myeloid lineage commitment were mediated by beta3 integrin on hematopoietic progenitors. PMID: 28846069
4. Del-1 intercepted oxLDL before its receptor binding to reduce atherogenesis PMID: 27784857
5. EDIL3-mediated activation of TGF-beta and ERK signaling could provide therapeutic implications for HCC. PMID: 25980764
6. Study identified Del-1 as an endogenous homeostatic factor of the CNS protecting from neuroinflammation in the course of CNS autoimmunity PMID: 25385367
7. Del-1 controls NF-kappaB-activated MIF production in macrophages. PMID: 24504014
8. The reciprocal regulation between Del-1 and inflammation may contribute to optimally balance the protective and the potentially harmful effects of inflammatory cell recruitment. PMID: 24416060
9. Bleomycin-induced pulmonary fibrosis increased collagen deposition and TGF-beta production in the lung of Del-1(-/-) mice. PMID: 24525119
10. Decreased Del-1 expression is associated with salivary gland inflammation in Sjogren syndrome. PMID: 24060278
11. Observed increased leukocyte accumulation, inflammation, and higher apoptosis in the adrenal glands of Del-1-deficient mice. Del-1 deficiency was also associated with reduced corticosterone and ACTH levels 24 hours after lipopolysaccharide administration. PMID: 23364949
12. Del-1 suppressed LFA-1-dependent recruitment of neutrophils and IL-17-triggered inflammatory pathology and may thus be a promising therapeutic agent for inflammatory diseases. PMID: 22447028
13. Del-1 plays a physiological role in the clearance of phosphatidylserine-expressing microparticles by endothelium. PMID: 22388320
14. The apoptosis-inducing activity of Del1 could be mapped to the third EGF motif, which fitted the consensus sequence CX(D/N)XXXX(F/Y)XCXC, wherein the aspartic acid residue (D) could be beta-hydroxylated. PMID: 20171188
15. mediates vascular smooth muscle cells adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3) PMID: 11959660
16. acts as an angiogenic factor in the context of solid tumor formation; the increase in vascularization accelerates tumor growth through decreased apoptosis PMID: 12074641
17. Del-1 is expressed in ischemic tissue. Del-1 stimulates angiogenesis, an effect that is dependent on the RGD motif and a second signaling sequence in the discoidin-I-like domain. PMID: 14981004
18. Demonstration of Del-1 and milk fat globule-EGF-factor 8 (MFG-E8) binding to phosphatidylserine exposed on apoptotic cells suggests the existence of macrophage subsets that use Del-1 or MFG-E8 differently to engulf apoptotic cells. PMID: 15004195
19. Del1 (Edil3) is induced by a number of growth factors/cytokines including VEGF, indicating the possible involvement of Del1 in tumor angiogenesis. PMID: 15964546
20. Fusion with the deposition domain of Del1 dramatically alters the distribution of exogenous proteins in mice. PMID: 17701220
21. Constitutive expression of Del1 in skin does not affect skin vascularity or improve wound healing. PMID: 17764695
22. Del-1 may participate in modulating cerebral angiogenesis, and that gene transfer of Del-1 may provide a novel and potent means for stimulating cerebral angiogenesis. PMID: 18534562
23. study describes Del-1 as an anti-adhesive factor that interferes with the integrin LFA-1-dependent leukocyte-endothelial adhesion; Del-1 is an endogenous inhibitor of inflammatory cell recruitment PMID: 19008446

Show More

Hide All

KEGG: mmu:13612

STRING: 10090.ENSMUSP00000080462

UniGene: Mm.125580