Mouse Gastrin-releasing peptide(GRP) ELISA kit

1. These data suggest that GRPR expression in fibroblast-like synoviocytes (FLS)and that exogenous GRP are able to activate FLS invasion. This effect occurs at least in part through the AKT activation. Therefore, understanding of the GRP/GRPR pathway could be relevant in the development of FLS-targeted therapy for Rheumatoid arthritis . PMID: 28733141
2. Fos and phosphorylation of extracellular signal-regulated kinases (ERK) were used to look for evidence that interneurons expressing GRP were activated following intradermal injection of chloroquine. PMID: 27270268
3. GrpmRNA and protein are upregulated in dorsal root ganglias, but not in the spinal cord, of mice with chronic itch. PMID: 27068287
4. GRP is expressed by a distinct population of excitatory interneurons in laminae I-II that are likely to be involved in the itch pathway PMID: 25496164
5. BNP-NPRA signaling is involved in both itch and pain and does not function upstream of the GRP-GRPR dedicated neuronal pathway. PMID: 24438367
6. nonamidated peptides derived from the C terminus of pro-GRP are expressed in significant quantities in colorectal cancer cell lines PMID: 22202166
7. GRP delays the phase of the clock during the early night by prolonging day-like membrane properties of SCN cells PMID: 21454290
8. The GRP receptor system does not mediate kappa opioid receptor antagonist (GNTI)-induced scratching. The kappa opioid system is involved, at least in part, in the scratch suppressing activity of the kappa opioid receptor agonist nalfurafine. PMID: 21126550
9. These studies demonstrate that (64)Cu-SarAr-SA-Aoc-bombesin(7-14) and (64)Cu-SarAr-SA-Aoc-GSG-bombesin(7-14) bound with high affinity to GRPR-expressing cells. PMID: 21321264
10. A general possible effect of GRP on cortical inhibitory transmission, was shown. PMID: 20836873
11. GRP/GRP-R play a transient and non-critical role in intestinal development PMID: 11960700
12. GRP has a role in regulation of fear and memory for fear in the mouse amygdala PMID: 12526815
13. Potential new role for gastrin-releasing peptide -BB2 signaling within the circadian clock. PMID: 16319315
14. New evidence for the occurrence of marked effects of bombesin/gastrin-releasing peptide concerning both the articular chondrocytes and the inflammatory process is obtained in this study PMID: 17911468
15. GRP nerve fibers were markedly high in the epidermis of atopic dermatitis mice PMID: 19571818

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KEGG: mmu:225642

STRING: 10090.ENSMUSP00000025395

UniGene: Mm.20298