Recombinant Mouse Gastrin-releasing peptide(Grp)

Code CSB-YP009940MO
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Source Yeast
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Code CSB-EP009940MO
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Source E.coli
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Code CSB-EP009940MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP009940MO
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Source Baculovirus
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Code CSB-MP009940MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Grp
Uniprot No. Q8R1I2
Alternative Names Grp; Gastrin-releasing peptide; GRP) [Cleaved into: Neuromedin-C; GRP-10)]
Species Mus musculus (Mouse)
Expression Region 24-52
Target Protein Sequence APVSTGA GGGTVLAKMY PRGSHWAVGH LM
Protein Length Cytoplasmic domain
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior
Gene References into Functions
  1. These data suggest that GRPR expression in fibroblast-like synoviocytes (FLS)and that exogenous GRP are able to activate FLS invasion. This effect occurs at least in part through the AKT activation. Therefore, understanding of the GRP/GRPR pathway could be relevant in the development of FLS-targeted therapy for Rheumatoid arthritis . PMID: 28733141
  2. Fos and phosphorylation of extracellular signal-regulated kinases (ERK) were used to look for evidence that interneurons expressing GRP were activated following intradermal injection of chloroquine. PMID: 27270268
  3. GrpmRNA and protein are upregulated in dorsal root ganglias, but not in the spinal cord, of mice with chronic itch. PMID: 27068287
  4. GRP is expressed by a distinct population of excitatory interneurons in laminae I-II that are likely to be involved in the itch pathway PMID: 25496164
  5. BNP-NPRA signaling is involved in both itch and pain and does not function upstream of the GRP-GRPR dedicated neuronal pathway. PMID: 24438367
  6. nonamidated peptides derived from the C terminus of pro-GRP are expressed in significant quantities in colorectal cancer cell lines PMID: 22202166
  7. GRP delays the phase of the clock during the early night by prolonging day-like membrane properties of SCN cells PMID: 21454290
  8. The GRP receptor system does not mediate kappa opioid receptor antagonist (GNTI)-induced scratching. The kappa opioid system is involved, at least in part, in the scratch suppressing activity of the kappa opioid receptor agonist nalfurafine. PMID: 21126550
  9. These studies demonstrate that (64)Cu-SarAr-SA-Aoc-bombesin(7-14) and (64)Cu-SarAr-SA-Aoc-GSG-bombesin(7-14) bound with high affinity to GRPR-expressing cells. PMID: 21321264
  10. A general possible effect of GRP on cortical inhibitory transmission, was shown. PMID: 20836873
  11. GRP/GRP-R play a transient and non-critical role in intestinal development PMID: 11960700
  12. GRP has a role in regulation of fear and memory for fear in the mouse amygdala PMID: 12526815
  13. Potential new role for gastrin-releasing peptide -BB2 signaling within the circadian clock. PMID: 16319315
  14. New evidence for the occurrence of marked effects of bombesin/gastrin-releasing peptide concerning both the articular chondrocytes and the inflammatory process is obtained in this study PMID: 17911468
  15. GRP nerve fibers were markedly high in the epidermis of atopic dermatitis mice PMID: 19571818

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Subcellular Location Secreted, Cytoplasmic vesicle, secretory vesicle lumen
Protein Families Bombesin/neuromedin-B/ranatensin family
Tissue Specificity Detected in the suprachiasmatic nucleus in the hypothalamus (PubMed:28280205). Detected in peptidergic dorsal root ganglion neurons (at protein level) (PubMed:17653196). Highly expressed both in the lateral nucleus of the amygdala, and in regions sending
Database Links

KEGG: mmu:225642

STRING: 10090.ENSMUSP00000025395

UniGene: Mm.20298

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