Mouse Tumor necrosis factor receptor superfamily member 17(TNFRSF17) ELISA kit

Code CSB-EL023974MO
Size 96T,5×96T,10×96T
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Trial Size 24T ELISA Kit Trial Size (Only USD$150/ kit)
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Product Details

Alternative Names
Tnfrsf17; Bcm; Bcma; Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD antigen CD269
Abbreviation
Uniprot No.
Species
Mus musculus (Mouse)
Sample Types
serum, plasma, tissue homogenates
Detection Range
0.39 ng/ml - 25 ng/ml.
Sensitivity
0.1 ng/ml.
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Immunology
Assay Principle
quantitative
Measurement
Sandwich
Troubleshooting
and FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Shelf Life
6 months
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx.
Description

This Mouse TNFRSF17 ELISA Kit was designed for the quantitative measurement of Mouse TNFRSF17 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 0.39 ng/ml- 20ng/ml and the sensitivity is 0.009 ng/ml.

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Target Background

Function
(From Uniprot)
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Gene References into Functions
  1. high affinity antibody blocks the binding of the native ligands APRIL and BAFF to BCMA. This finding is rationalized by the high resolution crystal structure of the Fab fragment in complex with the extracellular domain of BCMA PMID: 25953704
  2. Elimination of B lymphocyte stimulator receptor 3 (BR-3) and BCMA inhibits the development of SLE in NZM mice. PMID: 25989238
  3. we have identified a novel role for BCMA to control excess BAFF production in murine lupus through restraining the accumulation of BAFF-producing neutrophils. PMID: 25010693
  4. Heteromers consisting of one BAFF and two APRIL bind to receptor TACI, BCMA but not to BAFFR. PMID: 25953898
  5. BCMA is dispensable for the development of SLE in NZM mice. BAFF-BCMA interactions contribute to SLE. PMID: 23334904
  6. Study reveals that BCMA works to control B cell homeostasis and self-tolerance in systemic autoimmunity. PMID: 21536804
  7. Blimp-1 is a positive regulator of the expression of BCMA gene in mouse plasma cells. PMID: 20339926
  8. The 5'-flanking sequence from -820 to +145 bp of BCMA is of promoter activity. PMID: 18687216
  9. A vital role of BCMA in bone marrow plasma cell survival. PMID: 14707116
  10. B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells. PMID: 16116167
  11. Review. APRIL interactions with BCMA likely govern memory B cell populations. PMID: 16919470
  12. Review. Direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation. PMID: 16931039

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Subcellular Location
Membrane; Single-pass type III membrane protein.
Tissue Specificity
Detected in spleen, thymus, bone marrow and heart, and at lower levels in kidney and lung.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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