Mouse Tumor necrosis factor receptor superfamily member 17(TNFRSF17) ELISA kit

Code CSB-EL023974MO
Size 96T,5×96T,10×96T How to order?
Trial Size 24T ELISA kits trial application
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Product Details

Description

This Mouse TNFRSF17 ELISA Kit was designed for the quantitative measurement of Mouse TNFRSF17 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 39.06 pg/mL-2500 pg/mL and the sensitivity is 9.75 pg/mL.

Alternative Names Tnfrsf17; Bcm; Bcma; Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD antigen CD269
Abbreviation TNFRSF17
Uniprot No. O88472
Species Mus musculus (Mouse)
Sample Types serum, plasma, tissue homogenates
Detection Range 0.39 ng/ml- 20ng/ml
Sensitivity 0.009 ng/ml
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Immunology
Assay Principle quantitative
Measurement Sandwich
ELISA Data Analysis Watch ELISA data processing video & download Curve Expert if needed
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

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Target Background

Function
(From Uniprot)
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Gene References into Functions
  1. high affinity antibody blocks the binding of the native ligands APRIL and BAFF to BCMA. This finding is rationalized by the high resolution crystal structure of the Fab fragment in complex with the extracellular domain of BCMA PMID: 25953704
  2. Elimination of B lymphocyte stimulator receptor 3 (BR-3) and BCMA inhibits the development of SLE in NZM mice. PMID: 25989238
  3. we have identified a novel role for BCMA to control excess BAFF production in murine lupus through restraining the accumulation of BAFF-producing neutrophils. PMID: 25010693
  4. Heteromers consisting of one BAFF and two APRIL bind to receptor TACI, BCMA but not to BAFFR. PMID: 25953898
  5. BCMA is dispensable for the development of SLE in NZM mice. BAFF-BCMA interactions contribute to SLE. PMID: 23334904
  6. Study reveals that BCMA works to control B cell homeostasis and self-tolerance in systemic autoimmunity. PMID: 21536804
  7. Blimp-1 is a positive regulator of the expression of BCMA gene in mouse plasma cells. PMID: 20339926
  8. The 5'-flanking sequence from -820 to +145 bp of BCMA is of promoter activity. PMID: 18687216
  9. A vital role of BCMA in bone marrow plasma cell survival. PMID: 14707116
  10. B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells. PMID: 16116167
  11. Review. APRIL interactions with BCMA likely govern memory B cell populations. PMID: 16919470
  12. Review. Direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation. PMID: 16931039

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Subcellular Location Membrane; Single-pass type III membrane protein.
Tissue Specificity Detected in spleen, thymus, bone marrow and heart, and at lower levels in kidney and lung.
Database Links

KEGG: mmu:21935

STRING: 10090.ENSMUSP00000023140

UniGene: Mm.12935

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