This Mouse TNFRSF17 ELISA Kit was designed for the quantitative measurement of Mouse TNFRSF17 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 39.06 pg/mL-2500 pg/mL and the sensitivity is 9.75 pg/mL.
Tnfrsf17; Bcm; Bcma; Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD antigen CD269
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Gene References into Functions
high affinity antibody blocks the binding of the native ligands APRIL and BAFF to BCMA. This finding is rationalized by the high resolution crystal structure of the Fab fragment in complex with the extracellular domain of BCMA PMID: 25953704
Elimination of B lymphocyte stimulator receptor 3 (BR-3) and BCMA inhibits the development of SLE in NZM mice. PMID: 25989238
we have identified a novel role for BCMA to control excess BAFF production in murine lupus through restraining the accumulation of BAFF-producing neutrophils. PMID: 25010693
Heteromers consisting of one BAFF and two APRIL bind to receptor TACI, BCMA but not to BAFFR. PMID: 25953898
BCMA is dispensable for the development of SLE in NZM mice. BAFF-BCMA interactions contribute to SLE. PMID: 23334904
Study reveals that BCMA works to control B cell homeostasis and self-tolerance in systemic autoimmunity. PMID: 21536804
Blimp-1 is a positive regulator of the expression of BCMA gene in mouse plasma cells. PMID: 20339926
The 5'-flanking sequence from -820 to +145 bp of BCMA is of promoter activity. PMID: 18687216
A vital role of BCMA in bone marrow plasma cell survival. PMID: 14707116
B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells. PMID: 16116167
Review. APRIL interactions with BCMA likely govern memory B cell populations. PMID: 16919470
Review. Direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation. PMID: 16931039
Membrane; Single-pass type III membrane protein.
Detected in spleen, thymus, bone marrow and heart, and at lower levels in kidney and lung.