TNFRSF17, also known as B-cell maturation antigen (BCMA), is a transmembrane protein belonging to the tumor necrosis factor receptor superfamily. It is primarily expressed on mature B lymphocytes and plasma cells. BCMA binds to its ligands, APRIL and BAFF, promoting B-cell survival and differentiation. It is involved in the NF-κB and PI3K/AKT signaling pathways.
Dysregulation of BCMA is associated with multiple myeloma and certain autoimmune diseases. Due to its specific expression in plasma cells, BCMA has become an attractive target for drug development. Many novel therapies, such as bispecific antibodies and chimeric antigen receptor (CAR) T-cell therapies, are in various stages of clinical trials, showing promising results in treating multiple myeloma.
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized BCMA at 2 μg/ml can bind Anti-BCMA recombinant antibody, the EC50 of human BCMA protein is 1.912-2.488 ng/ml.
Measured by its binding ability in a functional ELISA. Immobilized TNFSF13B (CSB-MP897523HU1) at 10 μg/ml can bind human BCMA, the EC50 of human BCMA protein is 221.3-298.6 ng/ml.
Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.
Activity
Measured by its binding ability in a functional ELISA. Immobilized human BCMA at 5 μg/ml can bind Biotinylated human TNFSF13B (CSB-MP897523HU1-B), the EC50 is 0.1752-0.3657 ng/ml.
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TNFRSF17 Antibody (CSB-PA220479)
Validated Data
Western blot analysis of L929 293T MCF7 HELA using CD269 antibody. Antibody was diluted at 1:2000. Secondary antibody was diluted at 1:20000
Western blot analysis of K562/JK using CD269 antibody. Antibody was diluted at 1:2000. Secondary antibody was diluted at 1:20000
The following TNFRSF17 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
TNFRSF17 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA593360 | TNFRSF17 Antibody | Human,Mouse | ELISA,WB |
CSB-PA057490 | TNFRSF17 Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA220479 | TNFRSF17 Antibody | Human | WB, ELISA |
CSB-MA023974A0m | TNFRSF17 Monoclonal Antibody | Human | ELISA, WB, IHC |
CSB-MA023974A1m | TNFRSF17 Monoclonal Antibody | Human | ELISA, WB, IF, FC |
CSB-PA023974ZA01HU | TNFRSF17 Antibody | Homo sapiens | ELISA, WB (ensure identification of antigen) |
TNFRSF17 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-AP002271HU | Recombinant Human Tumor necrosis factor receptor superfamily member 17 protein (TNFRSF17), partial (Active) | E.coli |
CSB-MP023974HU1 | Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial (Active) | Mammalian cell |
CSB-EP023974HU1 | Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial | E.coli |
CSB-MP023974HU1-B | Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial,Biotinylated | Mammalian cell |
CSB-MP023974HU1h8 | Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial (Active) | Mammalian cell |
CSB-MP023974HU1d7 | Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial (Active) | Mammalian cell |
TNFRSF17 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF023974MO | Recombinant Mouse Tumor necrosis factor receptor superfamily member 17 (Tnfrsf17) | in vitro E.coli expression system |
CSB-YP023974MO1 CSB-EP023974MO1 CSB-BP023974MO1 CSB-EP023974MO1-B |
Recombinant Mouse Tumor necrosis factor receptor superfamily member 17 (Tnfrsf17), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
TNFRSF17 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL023974HU | Human Tumor necrosis factor receptor superfamily member 17(TNFRSF17) ELISA kit | serum, plasma, tissue homogenates | 1.95 pg/ml |
TNFRSF17 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL023974MO | Mouse Tumor necrosis factor receptor superfamily member 17(TNFRSF17) ELISA kit | serum, plasma, tissue homogenates | 0.1 ng/ml. |