Gene References into Functions |
- Diacerein reduces joint damage and hypersensitivity associated with inflammation induced by complete Freund's adjuvant through the inhibition of astroglial activation and decreases the expression of TRPV1 and MMP-9 in the rat spinal cord. PMID: 26481104
- Tubular Expression and Urinary Excretion of MMP-9 Protein Were Increased in Association with Albumin Overload in the Diabetic Kidneys. PMID: 28805677
- In conclusion, these results suggest that TEN exerts an anti-inflammatory effect by down-regulating the release of NO, MMP-9 and cytokines. PMID: 28392358
- Ang II is involved in the degradation of myosin light chain kinase in pressure overload-induced cardiac hypertrophy and that this process was mediated by MMP9. PMID: 29262413
- Jmjd3 mRNA depletion inhibited Mmp-3 and Mmp-9 gene expressions and significantly attenuated blood-spinal cord barrier permeability and the loss of tight junction proteins PMID: 27425890
- High MMP9 expression is associated with seizures. PMID: 28501723
- no significant relationship between plasma MMP-9 activity or aortic MMP-9 mRNA levels and the percentage of incomplete elastin lamellae or the aortic wall thickness PMID: 26547079
- High MMP9 expression is associated with uraemic vascular calcifications. PMID: 26333546
- that mesenchymal stem cells protect against obstruction-induced renal fibrosis, in part, by decreasing STAT3 activation and STAT3-dependent MMP-9 production PMID: 27760767
- absent in heterotopic ossification PMID: 26919547
- Results indicate that N-acetyl-cysteine (NAC) can effectively alleviate remifentanil-induced postoperative hyperalgesia (RIH) via powerfully inhibiting matrix metalloproteinase-9 (MMP-9)activation in dorsal root ganglia (DRGs). PMID: 28199982
- High mmp9 expression is associated with Retinitis Pigmentosa. PMID: 27893855
- Data suggest that increased blood pressure and decreased pup weight in ischemic model of pregnancy-induced hypertension are associated with decrease in Mmp9 homodimer and increase in Mmp9/Timp1 complex in placenta, uterus, and uterine artery; thus Mmp9 and Timp1 appear to be involved in uteroplacental/vascular remodeling in preeclampsia. (Mmp9 = matrix metalloproteinase 9; Timp1 = tissue inhibitor of metalloproteinase-1) PMID: 28506758
- PEX1 activation of the MMP-9 promoter triggers the pro-fibrotic response directed by PEX1. PMID: 27826738
- the up-regulation of MMP genes is mediated through degradation of class IIa histone deacetylases (HDACs) by certain cysteine cathepsins (Cts). PMID: 28157489
- Active fraction of tubers from Pueraria tuberosa (PTY-2)significantly attenuated the severity of diabetic nephropathy (DN) by increasing the expression and activity of matrix metalloproteinase-9 (Mmp-9). PMID: 26924185
- Therefore, the current study confirmed that MMP9 is important for the enhancement of the contractility of cerebrovascular smooth muscle cells in an in vitro rat model of subarachnoid hemorrhage PMID: 27633189
- Naringin has anti-fatigue effects which may be attributed to its property in modulating energy metabolism and reducing serum MMP-9 concentration. PMID: 27937032
- Alskiren attenuates signs of pulmonary fibrosis by decreasing pulmonary overexpression of MMP-9 and transforming growth factor beta1. PMID: 27154762
- Data suggest that, as non-alcoholic fatty liver disease progresses, expression of miR-21 (mirn21 microRNA), Mmp-9 (matrix metalloproteinase 9), and Timp-1 (tissue inhibitor of metalloproteinase-1) is up-regulated in liver, peaking when liver fibrosis is first detected; miR-21 has potential as a plasma biomarker for hepatic fibrosis. PMID: 27320964
- Atorvastatin reduced MMP9 levels in aging rat kidneys. PMID: 26680767
- Data suggests a mechanistic involvement of MMP-9 in aggravating hypertension-induced cerebrovascular pathologies. PMID: 26800984
- Our findings indicate that MMP9 may play an important role via inducing cell apoptosis in the development of diabetic retinopathy PMID: 26617754
- Increased circulating MMP-9 activity is associated with resistant albuminuria and a deleterious oxidative stress environment appears to be the underlying mechanism. PMID: 26733721
- Recombinant human BNP attenuates trauma/haemorrhagic shock-induced acute lung injury by inhibiting oxidative stress and PMID: 26852688
- This study demonstrated that stretching activated MMP-9 gene expressions and increased the proliferation of connective tissue but did not avoid muscle fiber atrophy or induce sarcomerogenesis of denervated rat soleus muscle PMID: 25960249
- MMP-9 expression was significantly increased in the gingiva in a model of gingival overgrowth. PMID: 25652432
- This study has shown a potential association of matrix metalloproteinase 9 with injury of the basilar artery and can be associated with early-stage brain injury following subarachnoid hemorrhage. PMID: 25627354
- Selective allosteric inhibition of MMP9 is efficacious in preclinical models of ulcerative colitis and colorectal cancer. PMID: 25961845
- In the presence of acute kidney injury in severe, acute pancreatitis, the renal expression of MMP-9 and VASP is related to damage of endothelial cells in capillaries, which reached a maximum at 24 h and declined afterwards. PMID: 26264698
- intestinal microbes with the capacity to produce collagenases and to activate host metalloproteinase MMP9 may break down collagen in the intestinal tissue contributing to anastomotic leak PMID: 25947163
- Data show that Ash1l and EZH2 methyltransferases protein expression was significantly elevated in fibrotic liver and decreased in mutant matrix metalloproteinase-9 (mMMP-9) and human hepatocyte growth factor (hHGF) gene transfer treated fibrotic livers. PMID: 25380300
- MMP-9 has a role in stress-induced downregulation of nectin-3 in hippocampal CA1 and associated behavioral alterations PMID: 25232752
- Up-regulation of reactive oxygen species-dependent matrix metalloproteinase-9 was found from high-glucose-challenged astrocytes PMID: 24395134
- The data indicated that early exercise significantly inhibited the ischemia-induced reduction of occludin, and an increase in MMP-9 promoted TIMP-1 expression. PMID: 23708107
- Inspiratory resistive breathing induces MMP-9 and -12 in the lung of previously healthy rats. PMID: 25595645
- Long term obesity creates environment promoting proliferative disorders in the prostate, leading to diffuse hyperplasia, via MMP9/VEGF pathway. PMID: 25529509
- Cold exposure-induced MMP-9 via activation of RAS might play a critical role in the initiation of cold exposure-induced stroke during chronic hypertension and doxycycline shows protective effects against cold exposure-induced stroke. PMID: 23800500
- Explored expression of MMP-9 and MDM2 in the oncogenesis of lung cancer in rats. PMID: 25063292
- Transient increases in brain MMP-9 levels are seen during cue-induced cocaine relapse. PMID: 25326689
- MMP-9 as a potential biomarker for osteosarcoma PMID: 24704305
- Curcumin attenuated hepatic ischemia/reperfusion-induced combined restrictive and obstructive lung disease by reducing lung inflammation and MMP-9 activity. PMID: 24815146
- In a rat mammary neoplasm model matrix metalloproteinase 9 had consistent localization throughout cancer cells, fibroblast and stroma. PMID: 25343559
- The location of Mmp9 and activity can be detected by means of in situ zymography and confocal microcopy, and this methodology may provide a useful tool in studies on the role of gelatinases in tooth development, maturation and in pathological conditions. PMID: 22897943
- MMP-9 induction is required for brain astrocyte migration. PMID: 24018979
- This study demonistrated that mmp9 throughout hippocampus at all ages but expression levels were highest during the first postnatal week. PMID: 24114974
- CCL19/CCR7 contributes to the migration of bone marrow mesenchymal stem cells by upregulating MMP9 potentially via the PI3K/Akt pathway. PMID: 25086360
- Matrix metalloproteinase-9, which is known to be activated by oxidative stress and S-nitrosylation of proteins, was suppressed more extensively by puerarin than losartan in diabetic rats. PMID: 24454919
- Fish oil treatment resulted in less severe hindlimb deficits after TBI as assessed with the beam walk test, decreased cerebral IgG infiltration, and decreased TBI-induced expression of the Mmp9 gene one day after injury. PMID: 24342130
- an overall inhibitory effect of curcumin on Gelatinase B in norepinephrine-induced hypertrophic stress in H9c2 cardiomyocytes which may contribute in the prevention of extracellular matrix remodeling. PMID: 24116115
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