Recombinant Human Growth/differentiation factor 7(GDF7)

Code CSB-AP005961HU
Size Pls inquire
Source E.Coli
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Product Details

Purity > 95 % as determined by SDS-PAGE and HPLC analyses.
Endotoxin Less than 0.1 EU/ug as determined by LAL method.
Activity Fully biologically active when compared to standard. The ED50 as determined by inducing alkaline phosphatase production of murine ATDC5 cells is less than 1.0 μg/ml, corresponding to a specific activity of > 1000 IU/mg.
Target Names GDF7
Uniprot No. Q7Z4P5
Research Area Signal Transduction
Alternative Names bmp12; bone morphogenetic protein 12; GDF-7; Gdf7; GDF7_HUMAN; growth differentiation factor 7; Growth/differentiation factor 7
Species Homo sapiens (Human)
Expression Region 322-450aa
Complete Sequence TALAGTRTAQ GSGGGAGRGH GRRGRSRCSR KPLHVDFKEL GWDDWIIAPL DYEAYHCEGL CDFPLRSHLE PTNHAIIQTL LNSMAPDAAP ASCCVPARLS PISILYIDAA NNVVYKQYED MVVEACGCR
Mol. Weight 14.0 kDa
Protein Length Full Length of Mature Protein
Tag Info Tag-Free
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer Lyophilized from a 0.2 um filtered concentrated solution in 30 % Acetonitrile and 0.1 % TFA.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

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Target Data

Function May play an active role in the motor area of the primate neocortex.
Gene References into Functions
  1. BMP-12 activates tenogenic pathway in human adipose stem cells. PMID: 28214472
  2. The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk. PMID: 26783083
  3. closest protein-coding genes were respectively GDF7 (rs3072), which encodes a ligand in the bone morphogenetic protein pathway, and TBX5 (rs2701108), which encodes a transcription factor that regulates esophageal and cardiac development PMID: 25447851
  4. BMP12 induces tenogenic differentiation of adipose-derived stromal cells via the Smad1/5/8 pathway. PMID: 24155967
  5. studies show that even though tenogenic (BMP 12 and BMP 13) and osteogenic (BMP2) BMPs bind the same receptors with high affinity they signal much differently and result in differential activation of osteogenic and tenogenic markers PMID: 21702718
  6. induces ligamentogenic differentiation in mesenchymal progenitors PMID: 20334610
  7. stimulates expression of both chondrogenic and osteoblstic markers in pluripotent mesenchymal C3H10T1/2 cells. PMID: 20102312
  8. In mouse, the expression of Gdf7 in roof plate cells is required for the fidelity of commissural axon growth. PMID: 12741987

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Subcellular Location Secreted
Protein Families TGF-beta family
Database Links

HGNC: 4222

OMIM: 604651

KEGG: hsa:151449

STRING: 9606.ENSP00000272224

UniGene: Hs.447688

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