Recombinant Mouse Fibroblast growth factor 9 (Fgf9) (Active)

1. stage-specific expression of FGF9 in XY gonads regulates different signal transduction pathways, ERK1/2 and p38, in XY primordial germ cells, resulting in the balance between proliferation and differentiation of the cells PMID: 28395336
2. the localization of FGF9 and its receptors at different embryonic and postnatal stages in mice testes, was examined. PMID: 27078042
3. results suggested that the combination of nCS (to support bone formation) with a fibrin-based VEGF/FGF9 release system (support vascular formation) is an innovative and effective strategy that significantly enhanced ectopic bone formation in vivo. PMID: 27269204
4. FGF9 is a crucial factor required for establishing an appropriate microenvironment for successful implantation and for pregnancy establishment. Additional analyses of pathways through which FGF9 participates in angiogenesis and endometrium-embryo communication should contribute to the understanding of molecular mechanisms that underlay process of implantation. PMID: 28848153
5. we conclude that the S99N mutation in Fgf9 causes multiple synostoses syndrome (SYNS) via the disturbance of joint interzone formation. These results further implicate the crucial role of Fgf9 during embryonic joint development PMID: 28169396
6. Our results suggest that mature osteoblasts are an important source of FGF9, positively regulating skeletal homeostasis in male mice PMID: 28189801
7. suggests FGF-9 has the potential to attenuate vascular cell apoptosis, activate c-Kit progenitor cells, and enhance angiogenesis and neovascularization in C57BL/6 and db/db mice leading to improved cardiac function. PMID: 26682010
8. Sox11 directly regulates the expression of Fgf9; ablation of the Sox11 gene results in clefting of the secondary palate resembling the Pierre Robin sequence. PMID: 26826126
9. data demonstrated that overexpressing FGF9 in PCa cells augmented the formation of reactive stroma and promoted PCa initiation and progression PMID: 26157349
10. These studies identify FGF9 as a target of DICER1 in lung epithelium that functions as an initiating factor for pleuropulmonary blastoma. PMID: 25978641
11. FGF-9 possesses novel therapeutic potential in its ability to mediate monocyte to M2 differentiation and confer cardiac protection in the post-infarction diabetic heart. PMID: 25768089
12. Data show that Fibroblast Growth Factors (FGF) 9 and 20 regulate the number of cochlear progenitors. PMID: 25915623
13. cerebellar microexplant cultures treated with an FGFR agonist or antagonist, we also show that FGF9/FGFR-mediated signaling inhibits the outward migration of radial glia and Bergmann glia precursors and cells PMID: 24983448
14. our data demonstrate that FGF9 can initiate a complex astrocytic response predicted to compromise remyelination, while at the same time stimulating microglial/macrophage recruitment in multiple sclerosis lesions PMID: 25907862
15. Demonstrate the complex role of FGF9-FGFR3 signalling in the initiation, growth and propagation of lung cancer. PMID: 25413587
16. FGF9 overexpression in lung leads to adenocarcinoma. PMID: 23867472
17. Loss of Fgf9 in XX Wnt4-/- gonads does not rescue their partial female-to-male sex-reversal. PMID: 22705479
18. The data suggested that, at a minimum, Fgf9/20 and Bmp7 organize the nephron progenitor niche. FGF signaling likely regulates multiple important steps in the niche, including survival, proliferation, and competence. PMID: 22698282
19. TGFbeta-FGF9-PITX2 signaling cascade regulates cranial neural crest cell proliferation during palate formation. PMID: 22123828
20. Data point to a role of Fgf9 signalling in primary and secondary lens fiber cell growth. PMID: 21858205
21. Data demonstrate that mesothelial- and epithelial-derived FGF9, mesenchymal Wnt2a and epithelial Wnt7b have unique functions in lung development in mouse. PMID: 21750028
22. Conditional expression of FGF9 promotes myocardial vascularization and hypertrophy with enhanced systolic function and reduced heart failure mortality after MI PMID: 21262993
23. Results suggest collectively that Fgf9 signalling from the outer mesothelial lining induce Spred/Sprouty expression in the underlying pancreatic mesenchyme. PMID: 20934536
24. Fgf9 stimulates steroidogenesis in postnatal Leydig cells. PMID: 19508331
25. data suggest a unique role for Fgf-9 in bone healing, presumably by initiating angiogenesis through Vegf-a PMID: 20547837
26. Data demonstrate that FGF9 can act as a diffusible conductor for a poleward expansion of tubulogenic programs at early phases of testis differentiation. PMID: 20040496
27. Recombinant fgf9 protein inhibits the differentiation response of the mesoderm to Shh, but does not affect proliferation. PMID: 12781691
28. Data show that Fgf9 is necessary for testis development, playing a role in the proliferation of cells that give rise to Sertoli progenitors and in the nuclear localization of FGF receptor R2 in Sertoli cell precursors. PMID: 15229180
29. To address the role of Fgf9 signaling, we analyzed the inner ears of mice homozygous for Fgf9 null alleles. Fgf9 inactivation leads to a hypoplastic vestibular component of the otic capsule and to the absence of the epithelial semicircular ducts. PMID: 15328018
30. FGF9 plays an important role in proliferation and organisation of embryonic Sertoli cells during testis morphogenesis PMID: 15470636
31. An epithelial FGF9 signal is necessary for the expansion of cecal mesenchyme and the expression of mesenchymal genes that are required for epithelial budding. PMID: 16308329
32. FGF9 acts on the lung mesenchyme to induce proliferation and decrease differentiation PMID: 16494859
33. FGF9 is necessary for 11.5 days post coitum fetal XY gonocyte survival and is the earliest reported factor with a sex-specific role in regulating germ cell survival. PMID: 16540514
34. the Sprouty proteins are involved normally in mediating the sexually dimorphic signaling of FGF9 and controlling cell migration from the mesonephros during testis development PMID: 16675530
35. The fate of the gonad is controlled by antagonism between Fgf9 and Wnt4. PMID: 16700629
36. Although Fgf9 is expressed in the apical ectodermal ridge in the limb bud, we demonstrate that the Fgf9-/- limb phenotype results from loss of FGF9 functions after formation of the mesenchymal condensation. PMID: 17544391
37. These data suggest a molecular mechanism through which FGF9 and sonic hedgehog signaling coordinately control the growth and patterning of the lung capillary plexus, and regulate the temporal and spatial expression of Vegfa. PMID: 17881491
38. The interaction of FGF and TGFbeta signaling pathways in the intestinal mesenchyme could represent novel targets for future short bowel syndrome therapies. PMID: 18653563
39. Results show that loss of fibroblast growth factor 9 or conditional inactivation of Fgf receptors (Fgfr) 1 and 2 in mouse lung mesenchyme results in ectopic airway smooth muscle cells. PMID: 19097117
40. A mechanism in which the range of FGF9 signaling in developing tissues is limited by its ability to homodimerize and its affinity for extracellular matrix heparan sulfate proteoglycans. PMID: 19219044
41. Neuron-derived Fgf9 is essential for scaffold formation of Bergmann radial fibers and migration of granule neurons in the cerebellum. PMID: 19232523
42. the PGD2 signaling pathway is likely to act independently of FGF9, thus implicating two independent feedforward loops between Sox9/Fgf9 and Sox9/L-Pgds in the coordination of growth, cell differentiation and morphogenesis of the gonad. PMID: 19429785

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KEGG: mmu:14180

STRING: 10090.ENSMUSP00000022545

UniGene: Mm.8846