Recombinant Horse Interleukin-1 Receptor Antagonist protein(IL1RN) (Active)

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Code CSB-AP003491HO
Product Type Interleukin
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Uniprot No. O18999
Lead Time 5-10 business days
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Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias Interleukin-1 receptor antagonist protein Short name: IL-1RN Short name: IL-1ra Short name: IRAP Alternative name(s): IL1 inhibitor
Species Equus caballus (Horse)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-1α- dependent proliferation of murine D10S cells is less than 3.0 μg/ml, corresponding to a specific activity of >333 IU/mg in the presence of 50 pg/ml rHuIL-1α.
Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence HPLGKRPCKM QAFRIWDVNQ KTFYMRNNQL VAGYLQESNT KLQEKIDVVP IEPDALFLGL HGRKLCLACV KSGDEIRFQL EAVNITDLSK NKEENKRFTF IRSNSGPTTS FESAACPGWF LCTAQEADRP VSLTNKPKES FMVTKFYLQE DQ
Research Area Immunology
Source E.coli
Gene Names IL1RN
Expression Region 26-177aa
Tag Info Tag-Free
Mol. Weight 17.4 kDa
Protein Description Full Length of Mature Protein
PubMed ID 19157767
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Function Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.
Subcellular Location Secreted
Protein Families IL-1 family
Database Links

KEGG: ecb:100034236

STRING: 9796.ENSECAP00000004056

UniGene: Eca.13123

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