Recombinant Human Interleukin-21(IL21),partial (Active) (GMP)

In StockGMP
Code CSB-AP005871HU
Product Type Interleukin
Size $6812
Uniprot No. Q9HBE4
Lead Time 5-10 business days
Storage Buffer Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Alias Za11,IL-21
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human N1186 T cells is less than 20 ng/ml, corresponding to a specific activity of > 5.0 × 104 IU/mg.
Purity > 98 % by SDS-PAGE and HPLC analyses.
Endotoxin Less than 0.01 EU/μg of rHuIL-21 GMP as determined by LAL method.
Sequence QGQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS
Research Area Immunology
Source E.Coli
Gene Names IL21
Expression Region 23-155aa
Tag Info Tag-Free
Mol. Weight 15.4 kDa
Protein Description Partial
PubMed ID 11081504; 17673207; 15815621; 15489334; 15178704; 15147560; 17565991; 22235133; 24746753
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Function Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Involvement in disease Immunodeficiency, common variable, 11 (CVID11)
Subcellular Location Secreted
Protein Families IL-15/IL-21 family
Tissue Specificity Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.
Database Links

HGNC: 6005

OMIM: 605384

KEGG: hsa:59067

STRING: 9606.ENSP00000264497

UniGene: Hs.567559

Pathway Jak-STAT signaling pathway
Th17 cell differentiation

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