Your Good Partner in Biology Research
Tel : 301-363-4651
Your Good Partner in Biology Research
| Code | CSB-AP001881HU |
| Product Type | Interleukin |
| Size |
US$112Purchase it in Cusabio online store (only available for customers from the US) |
| Uniprot No. | Q9HBE4 |
| Lead Time | 5-10 business days |
| Image | |
| Storage Buffer | 0.2 μm filtered PBS, pH 7.4 ,lyophilized |
| Alias | IL-21 |
| Species | Homo sapiens (Human) |
| Biological_Activity | Fully biologically active when compared to standard. The ED50 as determined by by a cell proliferation assay using human N1186 T cells is less than 20 ng/ml, corresponding to a specific activity of >5.0x104 IU/mg. |
| Purity | >97% as determined by SDS-PAGE and HPLC. |
| Endotoxin | Less than 1.0 EU/μg as determined by LAL method. |
| Sequence | QGQDRHMIRM RQLIDIVDQL KNYVNDLVPE FLPAPEDVET NCEWSAFSCF QKAQLKSANT GNNERIINVS IKKLKRKPPS TNAGRRQKHR LTCPSCDSYE KKPPKEFLER FKSLLQKMIH QHLSSRTHGS EDS |
| Research Area | Immunology |
| Source | E.coli |
| Gene Names | IL21 |
| Expression Region | 23-155aa |
| Tag Info | Tag-Free |
| Mol. Weight | 15.4 kDa |
| Protein Description | Full Length of Mature Protein |
| PubMed ID | 11081504; 17673207; 15815621; 15489334; 15178704; 15147560; 17565991; 22235133; 24746753 |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. |
| Involvement in disease | Immunodeficiency, common variable, 11 (CVID11) |
| Subcellular Location | Secreted |
| Protein Families | IL-15/IL-21 family |
| Tissue Specificity | Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. |
| Database Links |
HGNC: 6005 OMIM: 605384 KEGG: hsa:59067 STRING: 9606.ENSP00000264497 UniGene: Hs.567559 |
| Pathway |
Jak-STAT signaling pathway
Th17 cell differentiation |
IL21 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA872537ESR1HU | IL21 Antibody | Human | ELISA, IHC |
IL21 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA003027 | IL21 Antibody | Human,Mouse | WB,ELISA |
IL21 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-AP005871HU | Recombinant Human Interleukin-21(IL21),partial (Active) (GMP) | E.Coli |
| CSB-YP872537HU CSB-EP872537HU CSB-BP872537HU CSB-MP872537HU |
Recombinant Human Interleukin-21(IL21) | Yeast E.coli Baculovirus Mammalian cell |
IL21 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E11707h | Human Interleukin 21,IL-21 ELISA Kit | serum, plasma, tissue homogenates | 0.78 pg/mL |
Recombinant Hepatitis E virus genotype 3 Capsid protein(ORF2) ,partial
Express system: E.coli
Species: Hepatitis E virus genotype 3 (isolate Human/United States/US2) (HEV-3)
Recombinant Rat Alpha-1-antiproteinase(Serpina1)
Express system: Yeast
Species: Rattus norvegicus (Rat)
Recombinant Human Ras-related protein Rab-4A(RAB4A)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Alanine aminotransferase 1(GPT)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Tyrosine-protein kinase JAK1(JAK1),partial
Express system: Yeast
Species: Homo sapiens (Human)
Wait!
Join the 20,000 subscribers to get research hotpots, technical tips, latest information on events, sales and offers.
Sign up now to get your $50 coupon for protein expression service!
We don't deal in spam.
