Recombinant Mouse Interleukin-1 receptor antagonist protein (Il1rn)

1. Findings identify a critical role for IL1Ra in maintaining the natural diversity and composition of intestinal microbiota, and suggest a role for TLR4 in mucosal Th17 cell induction associated with the development of autoimmune disease in mice. PMID: 28645307
2. The current study is the first to demonstrate ex vivo airway hyperreactivity caused by systemic maternal inflammation and postnatal hyperoxia, and it reveals further preclinical mechanistic insights into IL-1Ra as a treatment targeting key pathophysiological features of Bronchopulmonary dysplasia. PMID: 27482635
3. we demonstrate that the release of IL1RA in response to genotoxic stress contributes to the immunosuppressive effects of apoptotic cells. PMID: 26873573
4. results provide evidence of the key role of IL1RA secreted by MSCs to both control the polarization of macrophages toward a M2 phenotype and inhibit B cell differentiation in vivo. PMID: 26661518
5. Allo-transplantation of mesenchymal stem cells reduces Con A liver injury by increasing IL10 production through an IL1Ra dependent macrophage switch. PMID: 26276675
6. results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra. PMID: 26951334
7. While both contributing to pathogen clearance, NLRP3 more than NLRC4 contributes to deleterious inflammatory responses in cystic fibrosis and correlates with defective NLRC4-dependent IL-1Ra production. PMID: 26972847
8. IL-1Ra deficiencies might promote early plaque development in 16-week-old apoE(-/-) mice. PMID: 26413013
9. IL-1Ra is associated with MMP-13 expression and has a novel function in such regulation without interference of the IL-1 signaling cascade. PMID: 26474296
10. These findings demonstrated novel roles for F-spondin and IL-1Ra in type B CpG oligodeoxynucleotides-mediated cell proliferation and migration of macrophages. PMID: 26042735
11. These findings demonstrate a pathogenic mechanism in which adaptive and innate immunity induce an autoimmune disease in a coordinated manner. PMID: 26108163
12. Leading to enhanced interleukin-1 receptor antagonist (IL-1RA) production. PMID: 25909959
13. IL-1Ra may have a protective effect upon EBOV infection. PMID: 26209680
14. IL-1ra regulates baseline GABAergic transmission in the central amygdala and is critical for the ethanol effects at these synapses. PMID: 25479427
15. normalization of IL-1Ra in obesity improved insulin sensitivity due to decreased inflammation in the liver and improved hepatic insulin sensitivity and these effects were independent of changes in body weight. PMID: 25244011
16. Loss of IL-1ra gene is associated with spontaneous arthritis. PMID: 21414240
17. We demonstrate that Aspergillus fumigatus galactosaminogalactan inhibits cytokines production by inducing Interleukin-1 receptor antagonist PMID: 24603878
18. IL-1Ra deficiency promoted the expression of inflammatory cytokines beyond IL-1 and altered the expression of genes involved in bone resorption in A. actinomycetemcomitans-infected osteoblasts. PMID: 24566623
19. IL-1rn(-/-) mice develop spinal abnormalities that resemble characteristic features associated with human intervertebral disc degeneration. PMID: 23396662
20. Modulation of the IL-1ra pathway by classical IL-6 signalling demonstrates anti-inflammatory and protective activities of IL-6 in vivo. PMID: 22980031
21. In the mouse ischemic heart and in a mouse cardiomyocyte cell line exposed to long-lasting hypoxia, IL-1ra bound and inhibited mitochondria-activated caspases. PMID: 23308180
22. Balb/c mice deficient in IL-1ra (mouse gene of IL-1RN) develop spontaneous autoimmune arthritis while DBA/1 mice deficient in IL-1ra do not PMID: 22942082
23. The results showed that CCR5 deficiency caused apoptotic cell death of melanoma through inhibition of NF-kappaB and upregulation of IL-1Ra. PMID: 22567084
24. The results showed that the local production of IL-1Ra by hepatocytes contributes to the resolution of hepatitis. The injured liver produced large amounts of IL-1Ra. The IL-1Ra isoforms were produced with different kinetics. PMID: 22539301
25. IL-1Ra plays an important role in suppressing local responses in eyes injected with LPS. PMID: 22267332
26. This gene is known to be important for immune responses and may potentially regulate alcohol consumption. PMID: 21309947
27. An imbalance in IL-1/IL-1Ra signaling at the IL-1R1 level modulates the severity of cardiac remodeling after acute myocardial infarction in the mouse. PMID: 22140485
28. Energy-sensing factors coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist. PMID: 22117073
29. infection of IL-1RA(-/-) mice with Leishmania major led to significantly worsened disease outcome with larger lesions, dramatically higher parasite burdens, and decreased IFN-gamma production by antigen-specific T cells PMID: 21525884
30. study demonstrates that intestinal epithelia, despite not expressing IL-1beta, secrete sIL-1Ra in a TLR5-dependent manner suggesting that loss of TLR5 may promote inflammation by increasing IL-1beta activity PMID: 20844479
31. these results show a protective effect of the IL-1ra in vivo in TLR9-associated liver injury. PMID: 20727895
32. Findins define distinct roles for two major cellular sources of IL-1Ra in response to different types of systemic inflammatory stimuli in vivo. PMID: 20639493
33. The development of psoriasis-like lesions in IL-1R antagonist (Il1rn)-deficient mice is dependent on locally produced tumor necrosis factor (TNF), but not on IL-6 or IL-17. PMID: 20610641
34. TLR4-mediated interleukin-1 receptor antagonist production plays a negative regulatory role in low molecular weight hyaluronan (200 kDa)-induced mouse lung inflammation, promoting an anti-inflammatory response. PMID: 20357263
35. IL-1Ra deficiency in inflammatory cells induced aortic valve inflammation and TNF-alpha participates in the development of aortic stenosis in IL-1Ra(-/-) mice. PMID: 20110570
36. MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages PMID: 19922413
37. Effect of MPC-11 myeloma and MPC-11 + IL-1 receptor antagonist treatment on mouse bone properties. PMID: 11792572
38. Balance between endogenous IL-1 and IL-1Ra during the primary immune response can help determine the antigen-specific effector function of T cells. PMID: 11810022
39. Regulation of transcription of the intracellular interleukin-1 receptor antagonist gene by AP-1 PMID: 11933077
40. Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size PMID: 11983917
41. highly expressed not only in liver and spleen, but also in white adipose tissue (WAT), where it is upregulated in obesity PMID: 12716739
42. Absence of IL-1Ra promoted neointimal formation in mice after arterial injury PMID: 12874179
43. CB1 and CB2 receptors modulate release of endogenous IL-1ra from primary cultured glial cells; endogenous IL-1ra is essential for the neuro-protective effects of CBs against excessive activation of glutamate receptors in cultured neurons PMID: 12878687
44. Sleep deprivation markedly increased interleukin 1 receptor antagonist, a natural (anti-inflammatory) modulator of interleukin-1. PMID: 14583241
45. IL-1Ra plays a role in the suppression of lesion development during early atherogenesis & in the modulation of plaque composition. PMID: 15059807
46. Data suggest that IL-1 receptor antagonist deficiency in T cells disrupts homeostasis of the immune system and that TNF-alpha plays an important role in activating T cells through induction of OX40. PMID: 15578092
47. hepatocyte-derived IL-1ra may control optimal activation and migration of inflammatory dendritic cells within the liver and thereby determine the local immune responses in granulomatous liver disease PMID: 15749858
48. IL-1Ra is an important regulator of adipogenesis, food intake, and energy expenditure, as seen in knockout mice. PMID: 16306368
49. IL-1Ra reduces insulin sensitivity in rats through a muscle-specific decrease in glucose uptake. PMID: 16385385
50. absence of IL-1ra may suppress TGF-beta-mediated signaling pathway, which is crucial for collagen deposition and vascular endothelial growth factor-mediated neovascularization in wound heali PMID: 16622029

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KEGG: mmu:16181

STRING: 10090.ENSMUSP00000110126

UniGene: Mm.882