Recombinant Mouse Interleukin-1 receptor antagonist protein(Il1rn) (Active)

In Stock
Code CSB-AP003271MO
Product Type Interleukin
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P25085
Lead Time 5-10 business days
Image
Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias IL-1RN, IRAP, IL1 inhibitor
Species Mus musculus (Mouse)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-1α- dependent proliferation of murine D10S cells is less than 50 ng/ml, corresponding to a specific activity of >2.0x104 IU/mg in the presence of 50 pg/ml rHuIL-1α.
Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence RPSGKRPCKM QAFRIWDTNQ KTFYLRNNQL IAGYLQGPNI KLEEKIDMVP IDLHSVFLGI HGGKLCLSCA KSGDDIKLQL EEVNITDLSK NKEEDKRFTF IRSEKGPTTS FESAACPGWF LCTTLEADRP VSLTNTPEEP LIVTKFYFQE DQ
Research Area Immunology
Source E.coli
Gene Names Il1rn
Expression Region 27-178aa
Tag Info Tag-Free
Mol. Weight 17.3 kDa
Protein Description Full Length of Mature Protein
PubMed ID 1828262; 1830498; 8003626; 9550387; 1828896; 1834470
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Function Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.
Subcellular Location Isoform 1: Secreted, SUBCELLULAR LOCATION: Isoform 2: Cytoplasm
Protein Families IL-1 family
Database Links

KEGG: mmu:16181

STRING: 10090.ENSMUSP00000110126

UniGene: Mm.882

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