Recombinant Mouse Interleukin-33 protein(Il33) (Active)

In Stock
Code CSB-AP003411MO
Product Type Interleukin
Size US$112Purchase it in Cusabio online store
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Uniprot No. Q8BVZ5
Lead Time 5-10 business days
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Storage Buffer 0.2 μm filtered PBS, and 1 mM EDTA ,lyophilized
Alias IL-33,; Interleukin-33109-266,]
Species Mus musculus (Mouse)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 0.5 ng/ml, corresponding to a specific activity of >2.0x106 IU/mg.
Purity >98% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence SIQGTSLLTQ SPASLSTYND QSVSFVLENG CYVINVDDSG KDQEQDQVLL RYYESPCPAS QSGDGVDGKK LMVNMSPIKD TDIWLHANDK DYSVELQRGD VSPPEQAFFV LHKKSSDFVS FECKNLPGTY IGVKDNQLAL VEEKDESCNN IMFKLSKI
Research Area Immunology
Source E.coli
Gene Names Il33
Expression Region 109-266aa
Tag Info Tag-Free
Mol. Weight 17.5 kDa
Protein Description Full Length of Mature Protein
PubMed ID 16286016; 16141072; 15489334; 19465481; 21734074; 22307629
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Function Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury.; FUNCTION
Subcellular Location Nucleus, Chromosome, Cytoplasmic vesicle, secretory vesicle, Secreted
Protein Families IL-1 family
Database Links

KEGG: mmu:77125

STRING: 10090.ENSMUSP00000025724

UniGene: Mm.182359

Pathway Necroptosis

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