ATG7 Monoclonal Antibody

Datasheet
Code CSB-MA617582
Product Type Monoclonal Antibody
Size US$167
Uniprot No. O95352
Research Use Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Image
  • Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma Tissue using ATG7 Mouse mAb diluted at 1:200.

Immunogen Recombinant Protein
Raised in Mouse
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,IHC;Recommended dilution:IHC:1:50-1:200
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Alias Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) (hAGP7) (Ubiquitin-activating enzyme E1-like protein)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.
Subcellular Location Cytoplasm, Preautophagosomal structure
Protein Families ATG7 family
Tissue Specificity Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.
Database Links

HGNC: 16935

OMIM: 608760

KEGG: hsa:10533

STRING: 9606.ENSP00000346437

UniGene: Hs.38032

Pathway Autophagy

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