COL3A1 Monoclonal Antibody

Code CSB-MA000282
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
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  • Western blot analysis of Hela, diluted at 1:1000.

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Product Details

Uniprot No. P02461
Target Names COL3A1
Alternative Names Alpha 1 type III collagen antibody; Alpha1 (III) collagen antibody; CO3A1_HUMAN antibody; COL 3A1 antibody; COL3A1 antibody; Collagen alpha 1(III) chain antibody; Collagen alpha-1(III) chain antibody; Collagen III alpha 1 chain precursor antibody; Collagen III alpha 1 polypeptide antibody; Collagen type III alpha 1 (Ehlers Danlos syndrome type IV autosomal dominant) antibody; Collagen type III alpha 1 antibody; Collagen type III alpha 1 chain antibody; Collagen type III alpha antibody; Collagen; fetal antibody; EDS4A antibody; Ehlers Danlos syndrome type IV; autosomal dominant antibody; Fetal collagen antibody; Type III collagen antibody
Raised in Mouse
Species Reactivity Human,Mouse,Rat
Immunogen Synthetic Peptide
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Form Liquid
Tested Applications ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

Customer Reviews and Q&A

 Customer Reviews
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Applications : WB

Sample dilution: 1: 1000

Review: Collagen type III. ANOVA, Dunnet: Control group is not different from any other group, P< .05. ANOVA, Tukey, *P<.05: K2w significantly different from UP2w and U4w. **2-week groups significantly different from 4-week groups regardless of PPNL treatment and suture technique.

By Anonymous

Applications : WB

Sample dilution: 1: 1000

Review: Type I collagen (A), type III collagen (B) and Integrin (D) were detected in similar amounts in the 3 experimental groups.

By Anonymous

Target Background

Function
(From Uniprot)
Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.
Gene References into Functions
  1. Elevated circulating PIIINP levels are associated with type 2 diabetes mellitus individuals with adipose tissue expansion and systemic proinflammatory profile suggestive for adipose tissue dysfunction. PMID: 29471595
  2. Reduced expression of types I and III collagen and TIMP-1 as well as the increased expression of MMP-1 and MMP-8 in the anterior vaginal wall tissues play important roles in the onset of pelvic organ prolapse. PMID: 29263043
  3. a variant of COL3A1 (rs3134646) is associated with the risk of developing colonic diverticulosis in white men, whereas rs1800255 (COL3A1) and rs1800012 (COL1A1) were not associated with this condition after adjusting for confounding factors. PMID: 29533249
  4. Brain MRI in the affected siblings as well as in the two previously reported individuals with bi-allelic COL3A1 mutations showed a brain phenotype similar to that associated with mutations in GPR56. PMID: 28258187
  5. Given the high specificity of the polymorphism at the rs1800255 locus of the COL3A1 gene, determined by the Sanger sequencing, it can be concluded that there is an association between this polymorphism and urinary incontinence and pelvic organ prolapse in women. PMID: 29376591
  6. Case Report: novel missense COL3A1 mutation in vascular Ehlers-Danlos syndrome patient presenting with pulmonary complications and iliac arterial dissection. PMID: 29216800
  7. Kaplan-Meir analysis of GSE7696 indicate that COL3A1 and SNAP91 correlated with survival. PMID: 27655637
  8. provide a picture of the gene expression changes in vascular Ehlers-Danlos syndrome skin fibroblasts and highlight that dominant negative mutations in COL3A1 also affect post-translational modifications and deposition into the ECM of several structural proteins crucial to the integrity of soft connective tissues PMID: 29346445
  9. We identified biallelic COL3A1 variants in two unrelated families. In a 3-year-old female with developmental delay the nonsense variant c.1282C>T, p.(Arg428*) was detected in combination the c.2057delC, p.(Pro686Leufs*105) frame shift variant. PMID: 28742248
  10. In conclusion, based on serological collagen formation and degradation makers, penetrating Crohn's disease is associated with increased matrix metalloproteinase-9 mediated breakdown of type III collagen PMID: 28481042
  11. Col3A may be a potential adjunct marker for both differentiating fibroadenoma from phyllodes tumor and assessing malignant potential in PTs. PMID: 27498063
  12. Case Report: pathogenetic heterozygous COL3A1 mutation c.3140 G>A, p. Gly1047Asp in Ehlers-Danlos syndrome vascular type with different phenotypes in the same family. PMID: 28183226
  13. von Willebrand factor A1 domain-collagen binding is independent of gain- or loss-of-function phenotype and under shear stress, platelet translocation pause times on collagen-bound A1A2A3 are either normal or shorter depending on whether A1 is concertedly bound with the A3 domain to collagen. PMID: 27889474
  14. High serum procollagen type III N-terminal peptide expression is associated with non-alcoholic fatty liver disease. PMID: 27442361
  15. The findings indicate the critical role of CatB in regulating the expression of collagens III and IV by fibroblasts via prolonging TLR2/NF-kappaB activation and oxidative stress. PMID: 27648120
  16. High COL3A1 expression is associated with colorectal carcinoma. PMID: 26741506
  17. novel missense mutation c.2176G>C in Chinese family with vascular Ehlers-Danlos syndrome PMID: 25420629
  18. High serum Collagen Type III is associated with ovarian and breast cancer. PMID: 26406420
  19. A novel missense mutation in COL3A1 was found in a young patient with cervical artery dissection as the single manifestation of Ehlers-Danlos syndrome. PMID: 26497932
  20. the clinical phenotype of Ehlers-Danlos syndrome patients is influenced by the type of COL3A1 variant. PMID: 25758994
  21. Report dysregulated expression of COL3A1 in disc degeneration. PMID: 25893343
  22. TGFbeta target genes including TGFBI, BAMBI, COL3A1 and SERPINE1 are significantly increased in Diamond Blackfan Anemia induced pluripotent stem cells PMID: 26258650
  23. The production and purification of rhCOL3A1 described in this study offer a new method for obtaining high level of rhCOL3A1 in relatively pure form, which is suitable for biomedical materials application. PMID: 25231012
  24. These results suggest that let-7d may suppress renal cell carcinoma growth, metastasis, and tumor macrophage infiltration at least partially through targeting COL3A1 and CCL7. PMID: 25193015
  25. compare reported phenotypes for patients with missense variants in the C-propeptide domain for other human collagen disorders including COL1A1 and COL1A2 (osteogenesis imperfecta). PMID: 25846194
  26. miR-29a and miR-29b enhance cell migration and invasion in nasopharyngeal carcinoma progression by regulating SPARC and COL3A1 gene expression. PMID: 25786138
  27. Data indicate that N-terminal propeptide of type III procollagen (PIIINP) is a highly effective means to evaluate left ventricular (LV) end-diastolic pressure (EDP) in patients with acute coronary syndrome (ACS). PMID: 25559610
  28. The first main finding of this study was that the rare COL3A1 rs1800255 AA genotype was associated with increased risk of anterior cruciate ligament injuries in the Polish cohort but not the South African cohort. PMID: 25073002
  29. During heart valve development, Krox20-mediated activation of fibrillar Col1a1 and Col3a1 genes is crucial to avoid postnatal degeneration of the aortic valve leaflets. PMID: 25344368
  30. In familial AAA we found one pathogenic and segregating variant (COL3A1 p.Arg491X), one likely pathogenic and segregating (MYH11 p.Arg254Cys), and fifteen VUS. PMID: 26017485
  31. rs1800255, COL3A1 2209 G>A polymorphism not associated with pelvic organ prolapse in Dutch population PMID: 24760181
  32. Variants of the COL3A1 gene are associated with a risk of stroke recurrence and prognosis. PMID: 24664438
  33. As a result of the translocations, COL3A1-PLAG1, the constitutively active promoter of the partner gene drives the ectopic expression of PLAG1. PMID: 24700772
  34. Gal-1 decreased the expression of collagen genes COL3A1 and COL5A1 but increased the expression of fibronectin and laminin 5. PMID: 24503541
  35. Arterial pathology in vascular Ehlers-Danlos syndrome individuals is related to the underlying COL3A1 mutation type. PMID: 24650746
  36. Expression of COL3A1 mRNA encoding key fibrotic extracellular matrix molecules was down-regulated by pre-miRNA-29b. PMID: 24641356
  37. The results point to the fact that the injury and/or mandible fracture increase the collagen type III metabolism and its dynamics depends on the type of the used bone fixation. PMID: 24421219
  38. Case Report: Ehlers-Danlos syndrome IV due to a mutation in intron 14 of the COL3A1 gene leading to venous manifestations without affecting arterial vessels at clinical presentation. PMID: 23688910
  39. Data suggest that cardiac fibrosis, as assessed by serum extracellular matrix protein biomarkers (including PIIINP, procollagen Type III-N-terminal peptide), develops early in hypertensive patients and is predictive of cardiovascular events or death. PMID: 22788708
  40. analysis of collagen folding in Vascular Ehlers-Danlos syndrome mutations PMID: 23645670
  41. COL3A1 rs1800255, COL6A1 rs35796750 and COL12A1 rs970547 were not significantly associated with sit-and-reach, straight leg raise or total shoulder rotation range of motion PMID: 23013106
  42. This study indicates that SP, mediated via NK-1 R, increases collagen remodeling and leads to increased MMP3 mRNA and protein expression that is further enhanced by cyclic mechanical loading. PMID: 22836729
  43. IL-17, IL-23 and PIIINP have an inverse correlation with vitamin D in their involvement in the immune response in patients with HCV-4-related liver diseases in Egypt PMID: 22851868
  44. study found that allele A of SNP rs1800255 conferred a 1.71-fold increased risk for intracranial aneurysms (IAs) and results in an amino acid change of Ala698Thr, which led to a lower thermal stability of the peptide; results support the view that the functional variant of COL3A1 is genetic risk factors for IAs in the Chinese population PMID: 22241462
  45. The minimum type III sequence necessary for cleavage by the MMP1 and MMP13 was 5 GXY triplets, including 4 residues before and 11 residues after the cleavage site (P4-P11'). PMID: 22573319
  46. Alveolar macrophages exposed to SiO2 can induce elevated type III procollagen and collagen III expression levels in human lung fibroblasts. PMID: 21941774
  47. Through alveolar macrophage mediation SiO2 can accelerate the expression of TIMP-1 and collagen III, and inhibit the expression of MMP-1 in human lung fibroblasts. PMID: 20039537
  48. procollagen III N-terminal peptide has a role in HBeAg loss in patients with chronic hepatitis B during entecavir therapy PMID: 22019950
  49. Disease-associated mutations prevent GPR56-collagen III interaction. PMID: 22238662
  50. Data show that homozygous and compound heterozygous changes found in PLOD1 and SLC2A10 may confer autosomal recessive effects, and three MYH11, ACTA2 and COL3A1 heterozygous variants were considered as putative pathogenic gene alterations. PMID: 22001912

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Involvement in disease Ehlers-Danlos syndrome 3 (EDS3); Ehlers-Danlos syndrome 4 (EDS4)
Subcellular Location Secreted, extracellular space, extracellular matrix
Protein Families Fibrillar collagen family
Database Links

HGNC: 2201

OMIM: 120180

KEGG: hsa:1281

STRING: 9606.ENSP00000304408

UniGene: Hs.443625

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