Code | CSB-MA999890 |
Size | US$166 |
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Application | Recommended Dilution |
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IHC | 1:20-1:200 |
The monoclonal antibody specifically against human KRT8 was generated using hybridoma technology. To begin the process, mice were immunized with a synthesized peptide derived from human KRT8, and then B cells were isolated from the spleen of the immunized mice. These B cells were then fused with myeloma cells to create hybridomas, from which hybridomas that continuously produce the KRT8 antibody were selected. The selected hybridoma was cultured in the mouse abdominal cavity. The KRT8 monoclonal antibody was purified from mouse ascites using specific immunogen affinity chromatography. It has been validated for use in ELISA and IHC applications.
KRT8 is expressed in epithelial cells, particularly in simple epithelia lining the cavities of the body, such as the digestive and respiratory tracts. KRT8 provides structural support and helps to maintain the integrity of the cytoskeleton, as well as protecting cells from mechanical stress and apoptosis. It also plays a role in signal transduction, cell migration, and tumor progression.
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