PPARD Monoclonal Antibody

Code CSB-MA294484
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  • Immunohistochemical analysis of paraffin-embedded Human Brain Tissue using PPAR Delta Mouse mAb diluted at 1:200.

  • Immunohistochemical analysis of paraffin-embedded Mouse Brain Tissue using PPAR Delta Mouse mAb diluted at 1:200.

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Product Details

Uniprot No. Q03181
Alternative Names FAAR antibody; MGC3931 antibody; NR1C2 antibody; NUC1 antibody; NUCI antibody; NUCII antibody; Nuclear hormone receptor 1 antibody; Nuclear receptor subfamily 1 group C member 2 antibody; Peroxisome proliferative activated receptor delta antibody; Peroxisome proliferator-activated receptor beta (PPAR-beta) antibody; Peroxisome proliferator-activated receptor beta antibody; Peroxisome proliferator-activated receptor delta antibody; PPAR beta antibody; PPAR-beta antibody; PPAR-delta antibody; PPAR-脽 antibody; PPARB antibody; ppard antibody; PPARD_HUMAN antibody
Raised in Mouse
Species Reactivity Human,Mouse,Rat
Immunogen Recombinant Protein of PPAR Delta of PPAR Delta
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Purification Method The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications ELISA,IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
Gene References into Functions
  1. Results suggest that peroxisome proliferator-activated receptor beta overexpression is not an inherent property of breast cancer cell lines, but it may play a role through activation of downstream genes (PPARbeta). PMID: 12009300
  2. 4 polymorphisms were found: -409C/T (promoter, +73C/T (exon 1), +255A/G (exon 3), & +294T/C (exon 4). An interaction with the PPAR alpha L162V polymorphism was also detected for several lipid parameters. PPARD plays a role in cholesterol metabolism. PMID: 12615676
  3. The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. PMID: 12909723
  4. results implicate PPAR-delta in the regulation of intestinal adenoma growth PMID: 14758356
  5. Positive associations of PPAR-delta polymorphisms with fasting plasma glucose and BMI detected in nondiabetic control subjects PMID: 14988273
  6. gene regulation by PPARdelta in the uterine cells uniquely responds to SRC-2, N-CoR, SMRT, or RIP140, and these interactions may be operative during implantation when these cofactors are abundantly expressed. PMID: 15001550
  7. PPAR-beta/delta activation stimulates keratinocyte differentiation, is anti-inflammatory, improves barrier homeostasis, and stimulates triglyceride accumulation in keratinocytes. PMID: 15102088
  8. 11beta-HSD2 is an additional target for PPAR delta, which may regulate human placental function PMID: 15591138
  9. This study was performed to determine whether specific activation of PPARdelta has direct effects on insulin action in skeletal muscle. PMID: 15793256
  10. COX-2 immunopositivity was significantly associated with PPARbeta and PPARgamma immunoreactivity. Microvessel density was significantly higher among PPARbeta-immunoreactive squamous cell carcinomas. PMID: 15811118
  11. PPARdelta signaling pathways are interconnected at the level of cross-regulation of their respective transcription factor mRNA levels PMID: 15890193
  12. PPARdelta expression is up-regulated between the first and third trimester, indicating a role for this nuclear receptor in placental function PMID: 15979543
  13. PPARdelta + 294T/C gene polymorphism in subjects with metabolic syndrome may be involved in the occurrence of obesity and dyslipidemia. PMID: 16053787
  14. PPARdelta partially rescued prostate epithelial cells from growth inhibition and also dramatically inhibited sulindac sulfide-mediated p21WAF1/CIP1 upregulation. PMID: 16091736
  15. PPARdelta +294T/C polymorphism has no influence on plasma lipoprotein concentrations, body mass index or atherosclerotic disease either in healthy subjects or in patients with DM-2, both in males and females. PMID: 16285997
  16. Single nucleotide polymorphisms of PPARD primarily affected insulin sensitivity by modifying glucose uptake in skeletal muscle but not in adipose tissue. PMID: 16306381
  17. The expression of PPARdelta gene in rectal cancers is not statistically different from normal mucosa. PMID: 16361076
  18. Human platelets contain PPARbeta and that its selective activation inhibits platelet aggregation. PMID: 16368717
  19. Data describe the activated form of the peroxisome proliferator-activated receptor-beta/delta using a ligand binding domain model. PMID: 16387648
  20. This review concludes that PPAR delta has emerged as a powerful metabolic regulator in diverse tissues including fat, skeletal muscle, and the heart. PMID: 16511591
  21. PGI2 protects endothelial cells from H2O2-induced apoptosis by inducing PPARdelta binding to 14-3-3alpha promoter, thereby upregulating 14-3-3alpha protein expression. PMID: 16645156
  22. data provide further evidence for an involvement of PPARdelta in the regulation of BMI. PMID: 16652134
  23. Skeletal muscle mRNA expression of PPAR delta increased in type 2 diabetic patients with an improved clinical profile following low-intensity exercise, but were unchanged in patients who did not show exercise-mediated improvements in clinical parameters. PMID: 16752430
  24. Single nucleotide polymorphisms in PPARD modify the conversion from glucose intolerance to type 2 diabetes. PMID: 16804087
  25. Therefore, these results indicate that induction of fatty acid oxidation with PPARbeta activators during short-term exposition is not sufficient to correct for insulin resistance in muscle cells from type 2 diabetic patients. PMID: 16897074
  26. PPARbeta/delta is a novel regulator of endothelial cell proliferation and angiogenesis through VEGF. PMID: 17068288
  27. PPARD-87T/C polymorphism is associated with higher fasting plasma glucose concentrations in both normal glucose tolerant and diabetic subjects, largely due to impaired insulin sensitivity PMID: 17116180
  28. PPAR-delta activation increases cholesterol export and represses inflammatory gene expression in macrophages and atherosclerotic lesions. PMID: 17119917
  29. support the rationale for developing PPARdelta antagonists for prevention and/or treatment of cancer PMID: 17148604
  30. These studies demonstrate that ligand activation of PPARbeta/delta does not lead to an anti-apoptotic effect in either human or mouse keratinocytes, but rather, leads to inhibition of cell growth likely through the induction of terminal differentiation. PMID: 17254750
  31. DNA sequence variation in the PPARdelta locus is a potential modifier of changes in cardiorespiratory fitness and plasma HDL-C in healthy individuals in response to regular exercise. PMID: 17259439
  32. Low PPARD expression is associated with Prostate Cancer Growth. PMID: 29187400
  33. Study demonstrates that oleanolic acid, as a natural product, can ameliorate the high glucose-triggered endothelial function by activating the nuclear receptor PPARdelta. PMID: 28067284
  34. PPARD rs7770619 is a novel candidate variant for impaired fasting glucose and type 2 diabetes and shows association with malondialdehyde levels. PMID: 29776318
  35. The negative responders for aerobic training are carriers of the PPARD rs2267668 G allele. The best responders to aerobic training are PPARD rs1053049 TT and rs2267668 AA. PMID: 29762540
  36. The current results suggest that A/A carriers of PPAR-delta SNP (rs2267668) may enjoy fewer beneficial effects of exercise-centered lifestyle intervention on anthropometric indices and blood measurements. PMID: 29494521
  37. Polymorphism of PPARD is associated with late onset of type 2 diabetes mellitus. PMID: 28292576
  38. findings suggest that PPARdelta conditions CLL cells to survive in harsh microenvironmental conditions by reducing oxidative stress and increasing metabolic efficiency. PMID: 28050012
  39. Here, theauthors describe a novel PPARbeta/delta-dependent molecular cascade involving TGFbeta1 and miR-21-3p, which is activated in the epidermis in response to UV exposure. PMID: 27250636
  40. findings identified previously unrecognized role of IP-PPARdelta signal transduction pathway in the production of sAPPalpha in cerebral microvasculature. PMID: 26661245
  41. the metabolic events, controlled by PPARs, occurring during neuronal precursor differentiation, the glucose and lipid metabolism was investigated. PMID: 27860527
  42. PPAR-delta activation prevents in-stent restenosis and stent thrombosis. PMID: 27283742
  43. findings identify LPCAT3 as a direct PPARdelta target gene and suggest a novel function of PPARdelta in regulation of phospholipid metabolism through LPCAT3. PMID: 27913621
  44. The minor allele of rs2016520 and rs9794 in PPAR-delta and interaction between rs2016520 and non-smoking were associated with decreased risk of CVD. PMID: 28287878
  45. a novel SNP x SNP interaction between rs2267668 in PPARdelta and rs7191411 in EMP2 that has significant impact on circulating HDL-C levels in the Singaporean Chinese population. PMID: 27530449
  46. Results indicate that PPARdelta-mediated downregulation of Nox4 modulates cellular redox status, which in turn plays a critical role in extracellular matrix homeostasis through ROS-dependent regulation of MMP-2 activity. PMID: 26403493
  47. The PPAR-beta role in neuroblastoma cell tumorigenesis and differentiation PMID: 27996177
  48. These observations candidate PPARs as new biomarkers of follicle competence opening new hypotheses on controlled ovarian stimulation effects on ovarian physiology. PMID: 26332656
  49. The PPAR delta role in neuroblastoma cell tumorigenesis and differentiation PMID: 27996177
  50. PPARdelta activation may be a potential risk of atherosclerosis through enhancing activity of SMS2 PMID: 27278004

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Subcellular Location Nucleus.
Protein Families Nuclear hormone receptor family, NR1 subfamily
Tissue Specificity Ubiquitous with maximal levels in placenta and skeletal muscle.
Database Links

HGNC: 9235

OMIM: 600409

KEGG: hsa:5467

STRING: 9606.ENSP00000310928

UniGene: Hs.696032

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