Recombinant Human Beta-defensin 103 protein(DEFB103A) (Active)

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Code CSB-AP003051HU
Product Type Other
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P81534
Lead Time 5-10 business days
Storage Buffer 0.2 μm filtered 20 mM PB, pH 7.4, 130 mM NaCl ,lyophilized
Alias Beta-defensin 3, DEFB-3, HBD3, hBD-3, Defensin, beta 103
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by anti-microbial activity against E.coli. is less than 30 μg/ml, corresponding to a specific activity of >33.3 IU/mg.
Purity >98% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Research Area Microbiology
Source E.coli
Gene Names DEFB103A
Expression Region 23-67aa
Tag Info Tag-Free
Mol. Weight 5.2 kDa
Protein Description Full Length of Mature Protein
PubMed ID 11085990; 11702237; 11223260; 11741980
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Function Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed.
Subcellular Location Secreted
Protein Families Beta-defensin family
Tissue Specificity Highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine.
Database Links

HGNC: 15967

OMIM: 606611

KEGG: hsa:414325

STRING: 9606.ENSP00000324633

UniGene: Hs.283082

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