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Recombinant Human Tumor Necrosis Factor Receptor Superfamily Member 17 (TNFRSF17) is a partial-length receptor produced in mammalian cells. A DNA sequence encoding the TNFRSF17 (1-54aa) was fused with an Fc-tag at C-terminal. Recombinant TNFRSF17 finds applications in studies involving cancer cells.
TNFRSF17 is a cell surface receptor usually expressed on B-cells. It is activated by ligands from the TNF 13b superfamily and TRAF family. On activation, it transmits signals that play a part in the activation of NF-kb and JNK/MAPK8 pathways.
In T-cell acute lymphoblastic leukemia and multiple myeloma, chromosomal errors in TNFRSF17 have been linked to aberrant activation of NF-kb and JNK. Aberrant activation of NF-kb and JNK pathways contributes to cancer-cell proliferation, metastasis, angiogenesis, and the inhibition of cancer-cell apoptosis.
The product has a molecular weight of 34.8 kDa, and purity levels over 90%, as verified using discontinuous SDS-PAGE. Its activity is verified with ELISA and LSPR assay.
Applications : ELISA standard and its raw materials
Review: We coated TNFRSF17 on the plate and performed a functional ELISA experiment with the ligand human TNFSF13B-Biotinylated, and the EC50 was 0.3101-0.5710 ng/ml, showing good binding activity. Since it will be used as standard in my subsequent experiment for activity testing, which requires high protein purity, low endotoxin, and good biological activity, CUSABIO\'s product has just met our needs perfectly, and the subsequent experiments have progressed smoothly!