Recombinant Human Tumor necrosis factor receptor superfamily member 17 protein(TNFRSF17),partial (Active)

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Code CSB-AP002271HU
Product Type Tumor Necrosis Factor
Size US$112Purchase it in Cusabio online store
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Uniprot No. Q02223
Lead Time 5-10 business days
Image
Storage Buffer 0.2 μm filtered 30 % acetonitrile, 0.1 % TFA ,lyophilized
Alias B-cell maturation protein
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit APRIL-mediated proliferation of anti-IgM stimulated murine B cells is no less than 40 ng/ml, corresponding to a specific activity of >2.5x104 IU/mg in the presence of 100 ng/ml human APRIL.
Purity >98% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA
Research Area Cancer
Source E.coli
Gene Names TNFRSF17
Expression Region 5-54aa
Tag Info Tag-Free
Mol. Weight 5.4 kDa
Protein Description Partial
PubMed ID 1396583; 8165126; 11528522; 17825416; 10493829; 15616553; 10903733; 10801128; 10973284; 10908663; 12721620; 15542592
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Function Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Involvement in disease A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
Subcellular Location Cell membrane, Single-pass type III membrane protein, Endomembrane system, Single-pass type III membrane protein
Tissue Specificity Expressed in mature B-cells, but not in T-cells or monocytes.
Database Links

HGNC: 11913

OMIM: 109545

KEGG: hsa:608

STRING: 9606.ENSP00000053243

UniGene: Hs.2556

Pathway Target Therapy

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