Recombinant Human Uteroglobin protein(SCGB1A1) (Active)

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Code CSB-AP000451HU
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Product Details

Purity >98% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity Fully biologically active when compared to standard. The ED50 as determined by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cells is less than 5.0 μg/ml, corresponding to a specific activity of >200 IU/mg.
Target Names SCGB1A1
Uniprot No. P11684
Research Area Immunology
Alternative Names Blastokinin; CC10; CC16; CCPBP; CCSP; Clara cell phospholipid binding protein; Clara cell phospholipid-binding protein; Clara cell specific 10 kD protein; Clara cells 10 kDa secretory protein; OTTHUMP00000236107; SCGB1A1; Secretoglobin family 1A member 1; Secretoglobin, family 1A, member 1 (uteroglobin); UG; UGB; UP-1; UP1; Urinary protein 1; Urine protein 1; UTER_HUMAN; Uteroglobin
Species Homo sapiens (Human)
Source E.Coli
Expression Region 22-91aa
Complete Sequence EICPSFQRVI ETLLMDTPSS YEAAMELFSP DQDMREAGAQ LKKLVDTLPQ KPRESIIKLM EKIAQSSLCN
Mol. Weight 7.9 kDa
Protein Length Full Length of Mature Protein
Tag Info Tag-Free
Form Lyophilized powder
Buffer Lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 7.4.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
Gene References into Functions
  1. There was no evidence that serum CC16 levels played a role in recurrent wheezing and a positive asthma predictive index in pre-school children PMID: 29685782
  2. Data suggest that the increase in plasma club cell protein (CC16) CC16 following inhaled allergen as a biomarker of epithelial dysfunction. PMID: 28862880
  3. We propose that increased CC-16 levels is a marker of lung inflammatory response that associated with ventilatory insufficiency are related to impending respiratory failure, not fully predicted by conventional respiratory tests PMID: 28967121
  4. Studied serum CC16 levels in The serum CC16 levels in Acute respiratory distress syndrome (ARDS) and non-ARDS patients; found CC16 to be were significantly higher in ARDS patients than that in non-ARDS patients. PMID: 28548310
  5. Studied serum CC16 levels in relation to atopy and previously manifested low respiratory tract diseases. Found low serum CC16 is associated with previously expressed pneumonia and chronic wheezing in atopic children. PMID: 28146340
  6. Our data suggest that rCC16 suppresses LPS-mediated inflammatory mediator TNF-alpha, IL-6, and IL-8 production by inactivating NF-kappaB and p38 MAPK but not AP-1 in RAW264.7 cells. PMID: 28338974
  7. There were associations between urinary CC16 and arsenic concentration in soil, water, house dust, and dust loading. In multiple analyses, only the concentration of arsenic in soil was associated with urinary CC16 levels after accounting for other factors. PMID: 27223295
  8. findings demonstrate that CC16 is upregulated in IPF patients suggesting that may participate in its pathogenesis. PMID: 27977812
  9. The G38A CCSP gene polymorphism may alter either the production of the protein and/or its activity in chronic obstructive pulmonary disease. PMID: 27496897
  10. CC16 levels differed among idiopathic pulmonary fibrosis, pulmonary sarcoidosis and chronic pulmonary obstructive disease. PMID: 27758987
  11. Lung-specific (CC-16) and novel (RelB) biomarkers are associated with systemic cardiovascular changes over time. CC-16 can predict subsequent exacerbations in subjects with severe COPD and may be an important biomarker of pulmonary and systemic stress in COPD. PMID: 26914709
  12. The serum concentration of CC16 was significantly higher in patients with lung fibrosis. PMID: 25244495
  13. lower levels of urine CC16 and lung function in patients with asthma than in those patients without asthma. CC16 in urine may be a useful tool or biomarker for investigating lung epithelium integrity among children with asthma or lung injury. PMID: 26108072
  14. Smokers and COPD patients had reduced airway CC16 immunostaining that decreased with increasing COPD severity. PMID: 25700379
  15. the uteroglobin G38A gene polymorphism was not associated with IgAN risk PMID: 25068828
  16. Sputum and bronchoalveolar lavage fluid CC16 were significantly higher in patients with severe asthma compared to mild-moderate asthma and healthy controls. PMID: 25728058
  17. In chromium-exposed workers, blood levels of CC16, and CC16/SP-D were lower than in controls. Positive relationships were shown between CC16 or CC16/SP-D and indicators of lung function. PMID: 25851191
  18. KL-6 levels were higher and CC16 levels were lower in infants with poor neurodevelopmental outcome compared with those infants who had favourable neurodevelopmental outcome. PMID: 25631862
  19. CC16 may play an important protective role in cigarette smoke-related diseases. PMID: 25635997
  20. A meta-analysis indicated that the CC16 gene A38G polymorphism is not associated with the risk of asthma. PMID: 25743006
  21. Increased plasma clara cell secretory protein levels are associated with primary graft dysfunction. PMID: 24400993
  22. Uteroglobin is a possible ligand of the lipoxin receptor and it may have a role in inhibiting serum amyloid A-driven inflammation PMID: 24782597
  23. Athletes with decreased serum CC16 from regular high-load exercise are more susceptible to respiratory infections. PMID: 24735334
  24. A single therapeutic dose of terbutaline offers significant protection against hyperpnoea-induced bronchoconstriction and reduces urinary CC16 protein levels. PMID: 24030662
  25. Lung permeability biomakers [surfactant protein D (SP-D) and Clara cell secretory protein (CC16) in plasma] and forced expiratory volumes and flow were measured in swimmers in indoor swimming pool waters treated with different disinfection methods. PMID: 23874631
  26. Serum CC-16 is associated with disease progression in chronic obstructive pulmonary disease (COPD). However, the absence of CC-16 does not appear to modify the risk of cigarette-related COPD in mice. PMID: 24245748
  27. Acute exposure to smoke induces injury at the alveolar level, which results in a transient increase of CC16 in serum of exposed subjects. PMID: 23258467
  28. These results suggest that the CC16 A38G polymorphism may play a role in asymptomatic airway hyper-responsiveness and contribute to the development of late-onset asthma. PMID: 24125144
  29. The SCGB1A1 +38A/G polymorphism is a risk factor for asthma. [Meta-analysis] PMID: 23820082
  30. urinary CC16 may be a useful biomarker of increased lung epithelial permeability among female non-smokers; further work will be required to evaluate its applicability to males PMID: 22805990
  31. Clara cell secretory protein expression changes is a relevant marker in the development of bronchiolitis obliterans patients with lung transplantation. PMID: 22883104
  32. Overview of CC16 in pathophysiology of and as a biomarker in chronic obstructive pulmonary disease. PMID: 23030587
  33. A Genome wide association study for COPD biomarkers on subjects with COPD found 2 discrete loci affecting CC16, one near the CC16 coding gene (SCGB1A1) on chromosome 11 and one approximately 25Mb away from SCGB1A1, identified in expressed sputum. PMID: 23144326
  34. Donor CCSP A38G polymorphism is associated with decreased CCSP levels early after lung transplantation and poor long-term outcomes. PMID: 22902791
  35. Exercise caused an increase in urinary excretion of CC16 in all subjects (P < 0.001), but this rise in CC16 was blunted following inhalation of warm humid air. PMID: 21799131
  36. demonstration that cc-10 is differentially expressed in infants with iRDS may point the way towards one possible mechanism that potentially involves modifications of the protein structure with its anti-inflammatory and surfactant protective function PMID: 22613976
  37. CC10 G+38A variant may contribute to the severity of asthma and lower level of steroid responsiveness. PMID: 22788242
  38. These results indicate that CC10 gene transfer may inhibit airway inflammation through suppressing the activation of NF-kappaB. PMID: 22558282
  39. Serum Clara cell secretory protein levels were characterized by an early postnatal surge. This apparent gestation-influenced surge may represent an initiation of a protective cascade against postnatal lung injury during extrauterine adaptation. PMID: 21952535
  40. Single-nucleotide polymorphism in the CC10 gene (A38G) does not seem to be involved in the severity of respiratory syncytial virus infection or wheezing. PMID: 21767304
  41. Urinary levels of CC16 are increased after eucapnic voluntary hyperpnea. PMID: 21131866
  42. Elevated circulating CC16 levels identified severe thoracic injury combined with a strong correlation with the extent/volume of affected lung tissue. PMID: 21045740
  43. CC16 38A/38A genotype plays a role in the development of early asthma in children with AR. PMID: 21255142
  44. Elevated plasma clara cell secretory protein concentration is associated with high-grade primary graft dysfunction. PMID: 21299834
  45. In the context of allergic airway responses, CC10 can inhibit OPN expression and suppress the Th2-promoting function of OPN, resulting in CC10's inhibitory biological effects. PMID: 20553297
  46. Data suggest that a supernatant of non-small-cell lung cancer causes an imbalance in the immune response of PBMCs and DCs, which is reversed by CC-10. PMID: 20664959
  47. Letter: serum CCSP cannot be used as a biomarker predictive for bronchiolitis obliterans after lung transplantation. PMID: 20683434
  48. Reduced anti-inflammatory CC10 concentrations in airways of extremely premature infants with a fetal inflammatory response, not umbilical cord serum CC10, might make their lungs susceptible for further postnatal injuries. PMID: 19887851
  49. Association of CC16 with daily outdoor particulate matter from combustion sources increases epithelial barrier permeability in lungs. PMID: 19852548
  50. The effect of G38A may be apparent under stimulation as sex steroids or infections, and homozygotes of the G38A mutation cannot produce sufficient UG in response to stimulation and may be predisposed to IgA nephropathy, especially in childhood. PMID: 11774099
  51. Role of uteroglobin G38A polymorphism in the progression of IgA nephropathy in Japanese patients. PMID: 11967037
  52. is a regulator of the inflammatory process in respiratory diseases PMID: 12014016
  53. Lys 43 and Asp 46 in rhUG are critical residues for the sPLA2-inhibitory activity of UG PMID: 12127976
  54. In IgA nephropathy, circulating UGB is not reduced and is even increased in IgA-Fn complexes, suggesting a feedback mechanism to downregulate the formation and circulation of IgA1-Fn complexes. PMID: 12200800
  55. COUP-transcription factors may play a pivotal role in cell specificity of the human CC10 gene by inhibiting its expression in nonpermissive cells PMID: 12204889
  56. CC16*A38G single-nucleotide polymorphism influences bronchial hyperreactivity and might be a genetic determinant of asthma severity in German children. PMID: 12642831
  57. results suggest that rP1 inhibits platelet aggregation by participation in the actin polymerization through which store mediated calcium entry is mediated PMID: 12927696
  58. G38A polymorphism in the CC10 gene may influence protein expression and be associated with the development of progressive sarcoidosis PMID: 14551164
  59. The presence of UG significantly correlated with the expression of estrogen receptor alpha and Progesterone rseceptor in endometrial cancer. PMID: 14719079
  60. uteroglobin expression is regulated by progesterone in the normal endometrium but regulation by progesterone receptor is lost in endometrial hyperplasia and carcinoma according to acquirement of tumorigenesis PMID: 14735466
  61. Uteroglobin G38A polymorphism had no association with the development of IgA nephropathy. PMID: 14990020
  62. Uteroglobin is an essential component of a novel innate homeostatic mechanism in the mammalian airways to repress allergen-induced inflammatory responses. PMID: 15148333
  63. Combination of CC16, GSTM1, and GSTT1 genetic polymorphisms is associated with asthma. PMID: 15148962
  64. These data provide new insights into the role of CC-10 in lung diseases and the possibility that the CC-10 concentration in serum could be a new marker indicating the severity of bronchial asthma. PMID: 15467329
  65. Uteroglobin suppresses SCCA gene expression associated with airway inflammation in asthma PMID: 15677460
  66. Polymorphism A38G and its role in asthma is studied. PMID: 15744536
  67. Reduction in anti-inflammatory activity by CC16 may contribute to the pathogenesis of allergic rhinitis. PMID: 15813809
  68. induction of uteroglobin expression has inhibitory effect on COX-2 expression in lung cancer cells via suppression of nuclear factor kappa-B activity PMID: 15829319
  69. uteroglobin plays important roles in maintaining homeostasis in organs that are vulnerable to inadvertent stimulation of FP-mediated inflammatory response by inhibiting the prostaglandin F2alpha receptor PMID: 16061484
  70. Given that inflammation may lead to functional compromise, these data suggest that early intervention with rhCC10 may enhance SF therapy. PMID: 16081627
  71. Subjects with CC16 38AA were more likely to have moderate or severe acute asthma. PMID: 16387800
  72. CC10 is detectable in the blood of newborn infants, and a production surge occurs at birth; surge is more pronounced in term infants and may confer them with superior extrauterine pulmonary protection compared with preterm infants PMID: 16690962
  73. These results do not support a role for UG in susceptibility to childhood Henoch-Schonlein purpura. PMID: 16703373
  74. Uteroglobin induces the development and cellular proliferation of the mouse early embryo. PMID: 17094107
  75. The genetic polymorphism in CC16 38 A/G is not associated with susceptibility to COPD in a southern Chinese population of Han nationality. PMID: 17207022
  76. The metabolic pathway of CC10 was studied. PMID: 17507989
  77. Uteroglobin is present in the human fallopian tube as a secretory protein and appears to be involved in immunosuppressive responses in the fallopian tube. PMID: 17531233
  78. Serum Clara cell protein 16(CC16) concentrations decreased in silica-exposed miners and may be a useful biomarker for early diagnosis of silicosis. PMID: 17693780
  79. study found that infant frequent wheezing is associated with the CC10 G+38A polymorphism and lower CC10 levels but not infant atopy PMID: 17716718
  80. Study provides evidence for the first time for AF-1 binding with uteroglobin(UG)-binding protein, and preliminarily characterized UG-binding protein as a point downstream of AF-1 in mediating ERK phosphorylation. PMID: 17928103
  81. Newborn piglets with meconium aspiration syndrome have physiologic dysfunction, inflammatory changes and histologic abnormalities, partially counteracted by a single dose of exogenous surfactant and CC10. PMID: 17957145
  82. Uteroglobin interacts with the heparin-binding site of fibronecti(Fn) and propose that small molecules competing for interaction with this site may reduce the level of circulating Fn-IgA complexes in immunoglobulin A (IgA)-nephropathy. PMID: 18243143
  83. Higher levels of the anti-inflammatory protein CC10 are associated with improvement in bronchial dysplasia PMID: 18316584
  84. CC16 protein is a peripheral blood biomarker of lung injury in ventilated preterm neonates. PMID: 18521628
  85. The CC10 A + 38G SNP may not exert a substantial influence on the development of CRS in the Chinese Han population. PMID: 18702901
  86. serum CC16 levels elevated in children with respiratory syncytial virus infection PMID: 18976364
  87. CC10 may take part in the pathogenesis of CRS and correlates with disease severity. Different cytokines can regulate CC10 expression in nasal mucosa differentially through modulating mRNA stability and certain transcriptional factors expression. PMID: 19076932
  88. SCGB1A1 A38G may play a role in the development and persistence of the asthma phenotype in childhood. PMID: 19128353
  89. propose that CC16 may down-modulate the entry of human eosinophils and neutrophils into the airways during inflammation in the lung PMID: 19132521
  90. Data show that comparing with similar fusion proteins in which uteroglobin was not used, the use of uteroglobin improved properties of solubility and stability. PMID: 19632988
  91. CC10 was the most down-regulated gene in human nasal polyp tissues studied by means of DNA microarray PMID: 15480316

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Subcellular Location Secreted
Protein Families Secretoglobin family
Tissue Specificity Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).
Database Links

HGNC: 12523

OMIM: 192020

KEGG: hsa:7356

STRING: 9606.ENSP00000278282

UniGene: Hs.523732

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