Recombinant Macaca fascicularis Cadherin 6(CDH6),partial (Active)

Cadherin 6 mediates calcium-dependent cell–cell adhesion in neural and renal tissues and has emerged as a biomarker in several cancers, where aberrant expression correlates with metastatic potential. This recombinant protein spans residues 22–614, encompassing the extracellular cadherin repeats critical for homophilic binding, and demonstrates specific antibody recognition with an EC50 of 2.076–2.371 ng/mL in functional ELISA, confirming proper epitope presentation. The quantified binding activity supports use in antibody development and validation workflows, where precise epitope mapping and affinity measurements are essential, as well as in cell adhesion and migration assays investigating cadherin-mediated tumor cell behavior. Produced in mammalian cells to preserve native glycosylation and folding, the protein meets the purity (>95% by SEC-HPLC) and endotoxin (<1.0 EU/μg) thresholds commonly required for functional cell-based assays and protein–protein interaction studies in cancer metastasis research.