Recombinant Macaca fascicularis Parathyroid hormone (PTH) (Active)

Parathyroid hormone orchestrates calcium homeostasis through G protein–coupled receptor signaling, making authentic primate orthologs essential for translational metabolic research. This cynomolgus monkey PTH spans the complete mature sequence (residues 32–115) and demonstrates quantified receptor engagement, binding immobilized PTH1R with an EC50 of 346.7–417.7 ng/mL in functional ELISA—a result that supports its use in receptor competition assays, cAMP induction studies, and structure-function mapping of PTH–PTH1R interactions. The mammalian expression system and C-terminal hFc1 tag provide native glycosylation and extended serum half-life, features that align with standards expected in pharmacokinetic studies and in vivo models of bone metabolism or mineral ion dysregulation. Endotoxin levels below 1.0 EU/μg and purity exceeding 95% satisfy the criteria typical for cell-based signaling assays and antibody development workflows where contaminant interference must be minimized.