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Recombinant Macaca fascicularis tyrosine-protein kinase Mer (MERTK), Partial (Active)

Recombinant Macaca fascicularis tyrosine-protein kinase Mer (MERTK), Partial (Active)

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Code	CSB-MP6050MOV
Abbreviation	Recombinant Cynomolgus monkey MERTK protein, partial (Active)
MSDS	MSDS Datasheet
Size	$118
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel. Activity Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus MERTK at 2 μg/ml can bind Anti-MERTK recombinant antibody (CSB-RA621519A1HU). The EC₅₀ is 23.48-26.59 ng/mL. Biological Activity Assay
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Product Details
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Product Details

Activity

Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus MERTK at 2 μg/mL can bind Anti-MERTK recombinant antibody (CSB-RA621519A1HU). The EC50 is 23.48-26.59 ng/mL.

Target Names

MERTK

Uniprot No.

XP_005575320.1

Species

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Source

Mammalian cell

Expression Region

23-507aa

Target Protein Sequence

AITEAREEAKPYPLFPGPLPGSLQTDHTSLLSLPHTSGYQPALMFSPTQPGRPYTGNVAIPRVTSAGSKLLPPLAFKHTVGHIILSEHKDVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIHNSTAHSILISWVPGFDGYSPFRNCSVQVKEVDPLSNGSVMIFNTSASPHMYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESRDNVDIRWMKPLTKRQAGELVGYRISHVWQSAGISKELLEEVGQNNSRAQISVQVHNATCTVRIAAVTKGGVGPFSDPVKIFIPAHGWVDHAPSSTPAPGNADPVLII

Mol. Weight

54.1 kDa

Protein Length

Partial

Tag Info

C-terminal 10xHis-tagged

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

MERTK mediates efferocytosis and dampens inflammatory signaling in the nervous system, making it a critical target for understanding microglial function and neuroinflammatory disease mechanisms. This mammalian-expressed extracellular domain (aa 23–507) demonstrates quantified antibody-binding activity with an EC50 of 23.48–26.59 ng/mL in functional ELISA, providing a validated reagent for therapeutic antibody epitope mapping, competitive inhibition screening, and blocking antibody validation studies. The measured binding kinetics support use in surface plasmon resonance and biolayer interferometry experiments designed to characterize antibody-receptor affinity or screen biologic inhibitors targeting the MERTK ectodomain. Purity exceeding 95% by SDS-PAGE and endotoxin levels below 1.0 EU/μg align with standards expected in ligand-receptor interaction assays and antibody development workflows where low contaminant interference is essential.