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Recombinant Rat Cadherin-6 (Cdh6), partial (Active)

Recombinant Rat Cadherin-6 (Cdh6), partial (Active)

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Code	CSB-MP005055RA1
Abbreviation	Recombinant Rat CDH6 protein, partial (Active)
MSDS	MSDS Datasheet
Size	$9.9
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel. Activity Measured by its binding ability in a functional ELISA. Immobilized Rat CDH6 at 2 μg/ml can bind Anti-CDH6 recombinant antibody (CSB-RA005055MA1HU). The EC₅₀ is 1.630-1.837 ng/mL. Biological Activity Assay The purity of CDH6 was greater than 95% as determined by SEC-HPLC
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Target Background

Product Details

Purity

≥ 95% as determined by SDS-PAGE.
≥ 95% as determined by SEC-HPLC.

Endotoxin

Less than 1.0 EU/ug as determined by LAL method.

Activity

Measured by its binding ability in a functional ELISA. Immobilized Rat CDH6 at 2 μg/mL can bind Anti-CDH6 recombinant antibody (CSB-RA005055MA1HU). The EC50 is 1.630-1.837 ng/mL.

Target Names

CDH6

Uniprot No.

P55280

Alternative Names

Kcad

Species

Rattus norvegicus (Rat)

Source

Mammalian cell

Expression Region

19-615aa

Target Protein Sequence

TFSNPLSKRTSGFPAKRRALELSANSRNELSRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKDVYTATVPEMADVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGHDMFDVITDQETQEGIITVKKLLDFEKKRVYTLKVEASNPHIEPRFLYLGPFKDSATVRIVVDDVDEPPVFSKPAYILQIREDAQINTTIGSVAAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGA

Mol. Weight

67.8 kDa

Protein Length

Partial

Tag Info

C-terminal 10xHis-tagged

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

Cadherin-6 mediates calcium-dependent homophilic cell adhesion in neural tissues and plays critical roles in morphogenesis, synaptogenesis, and tumor invasion. This recombinant fragment spans residues 19–615, encompassing the five extracellular cadherin domains essential for adhesive function, and demonstrates specific antibody binding with an EC50 of 1.630–1.837 ng/mL in functional ELISA, confirming proper epitope presentation. The quantified binding activity supports use in antibody development and validation workflows, while the mammalian expression system provides native glycosylation patterns that align with standards expected in cell adhesion and spreading assays, as well as cell migration and invasion studies investigating neural development or metastatic mechanisms. Purity exceeding 95% and endotoxin levels below 1.0 EU/μg meet the quality thresholds commonly required for functional assays where cell viability and receptor-mediated responses must remain uncompromised.

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Target Background

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Gene References into Functions