|Have Questions?||Leave a Message or Start an on-line Chat|
The 2-hydroxyisobutyryl-HIST1H1C (K109) Antibody was raised in a rabbit using a peptide around the site of 2-hydroxyisobutyryl-Lys (109) derived from Human Histone H1.2 as the immunogen. It’s a polyclonal, non-conjugated, IgG purified by antigen affinity. It finds uses in ELISA, Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), and Chromatin Immunoprecipitation (ChIP). This antibody reacts against the human histone HIST1H1C. It can detect the endogenous levels of HIST1H1C of human-origin. At the moment, there’s no function assigned to the K109 2-hydroxyisobutyryl modified lysine, and it’s still in need to be dilucidated. The HIST1H1C protein interacts with the linker DNA between nucleosomes, facilitating the chromatin condensation to higher-order fibers. And this histone also can affect the nucleosome spacing, chromatin remodeling, and DNA methylation, consequently modulating the gene expression. Therefore, it is vital for correct chromatin high structure formation, regulation, and maintenance.
|Full Product Name||Rabbit anti-Homo sapiens (Human) HIST1H1C Polyclonal antibody|
H1 histone family member 2 antibody; H1.a antibody; H12_HUMAN antibody; H1F2 antibody; H1s-1 antibody; HIST1H1C antibody; Histone 1 H1c antibody; Histone cluster 1 H1c antibody; Histone H1.2 antibody; Histone H1c antibody; Histone H1d antibody; Histone H1s-1 antibody; MGC3992 antibody
|Immunogen||Peptide sequence around site of 2-hydroxyisobutyryl-Lys (109) derived from Human Histone H1.2|
|Immunogen Species||Homo sapiens (Human)|
|Purification Method||Antigen Affinity Purified|
|Concentration||It differs from different batches. Please contact us to confirm it.|
|Buffer||Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
|Tested Applications||ELISA, WB, ICC, IF, ChIP|
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
Native Chromatin Immunoprecipitation(ChIP) Protocol
|Troubleshooting and FAQs||Antibody FAQs|
|Storage||Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.|
|Lead Time||Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.|
There are currently no reviews for this product.
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.
|Gene References into Functions||
|Subcellular Location||Nucleus. Chromosome. Note=Mainly localizes in euchromatin. Distribution goes in parallel with DNA concentration.|
|Protein Families||Histone H1/H5 family|