ACOX1 Antibody

Datasheet

Code	CSB-PA617998HA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA617998HA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA617998HA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA617998HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
Citations
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ACOX1 Polyclonal antibody

Uniprot No.

Q15067

Target Names

ACOX1

Alternative Names

ACOX antibody; ACOX1 antibody; ACOX1_HUMAN antibody; Acyl CoA oxidase 1 palmitoyl antibody; Acyl CoA oxidase straight chain antibody; AOX antibody; EC 1.3.3.6 antibody; PALMCOX antibody; Palmitoyl CoA oxidase antibody; Palmitoyl-CoA oxidase antibody; Peroxisomal acyl coenzyme A oxidase 1 antibody; Peroxisomal acyl-coenzyme A oxidase 1 antibody; Peroxisomal fatty acyl CoA oxidase antibody; SCOX antibody; Straight chain acyl CoA oxidase antibody; Straight-chain acyl-CoA oxidase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Peroxisomal acyl-coenzyme A oxidase 1 protein (113-273AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ACOX1 Antibody (Product code: CSB-PA617998HA01HU) is Non-conjugated. For ACOX1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA617998HB01HU	ACOX1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA617998HC01HU	ACOX1 Antibody, FITC conjugated
Biotin	CSB-PA617998HD01HU	ACOX1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

Deficiency of peroxisomal NUDT7 stimulates de novo lipogenesis in hepatocytes J Song,iScience,2022

Customer Reviews and Q&A

■ Customer Reviews

Average Rating:

5.0 - 1 reviews

Submit a Review here

Applications : Immunostainings

Sample type: cell

Review: Representative images of ACOX1, FASN, PPARγ, and SCD1 staining. The transcription levels of genes involved in lipid metabolism, such as Acaca, Cd36, Fasn, Fabp4, and Scd1, were dramatically increased in the liver of shAcox1-infected (shACOX1) NCD mouse.

By Anonymous

Target Background

Function

Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. First enzyme of the fatty acid beta-oxidation pathway.; Shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length.; Is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA.

Gene References into Functions

Because patients with AOx deficiency suffer from more severe symptoms than those with X-ALD, accumulation of VLC-PUFA and/or reduction of DHA may be associated with the severity of peroxisomal diseases. PMID: 24418004
ACOX1 and GNPAT silencing up-regulated ceramide galactosyltransferase (UGT8) mRNA expression, and down-regulated UDP-glucoseceramide glucosyltransferase (UGCG). PMID: 23933200
Data show that human ACOX1b isoform is more effective than the ACOX1a isoform in reversing the Acox1 null phenotype in the mouse. PMID: 20195242
Mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency. PMID: 17458872
report on two new patients with ACOX1 deficiency and mutational analyses PMID: 18536048

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Involvement in disease

Adrenoleukodystrophy, pseudoneonatal (Pseudo-NALD)

Subcellular Location

Peroxisome.

Protein Families

Acyl-CoA oxidase family

Tissue Specificity

Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Level

Database Links

HGNC: 119

OMIM: 264470

KEGG: hsa:51

STRING: 9606.ENSP00000293217

UniGene: Hs.464137

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

cAMP signaling pathway PPAR signaling pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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