ACOX2 Antibody

Datasheet

Code	CSB-PA246246
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA246246(ACOX2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA246246(ACOX2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200) Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse liver tissue, Mouse kidney tissue, Primary antibody: CSB-PA246246(ACOX2 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
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Product Details
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Target Background

Product Details

Uniprot No.

Q99424

Target Names

ACOX2

Alternative Names

12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase antibody; 12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase antibody; 3 alpha 7 alpha 12 alpha trihydroxy 5 beta cholestanoyl CoA oxidase antibody; 3 alpha 7 alpha12 alpha trihydroxy 5 beta cholestanoyl CoA 24 hydroxylase antibody; 3-alpha antibody; 7-alpha antibody; ACOX 2 antibody; ACOX2 antibody; ACOX2_HUMAN antibody; Acyl CoA oxidase 2 antibody; Acyl Coenzyme A oxidase 2 antibody; Acyl Coenzyme A oxidase 2 branched chain antibody; Acyl coenzyme A oxidase 2 peroxisomal antibody; BCOX antibody; BRCACOX antibody; BRCOX antibody; Peroxisomal acyl-coenzyme A oxidase 2 antibody; Peroxisomal branched chain acyl CoA oxidase antibody; THCA CoA oxidase antibody; THCA-CoA oxidase antibody; THCCox antibody; Trihydroxycoprostanoyl CoA oxidase antibody; Trihydroxycoprostanoyl-CoA oxidase antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Fusion protein of Human ACOX2

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:25-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids. Capable of oxidizing short as well as long chain 2-methyl branched fatty acids.

Gene References into Functions

We have identified by the first time in a young patient and his only sister a familiar genetic defect of an enzyme called ACOX2, which participates in the transformation of cholesterol into bile acids as a cause of increased serum transaminases in the absence of any other symptomatology. PMID: 27884763
Results found an ACOX2 variant present in a subset of human breast cancers and associated with improved outcome ER+ tumors suggesting it as a potential novel therapeutic biomarker in ER+ breast tumors. PMID: 26183823
Our results suggest that downregulation of ACOX2 is a shared risk factor for PE and CVD. PMID: 21343950

Involvement in disease

Congenital bile acid synthesis defect 6 (CBAS6)

Subcellular Location

Peroxisome.

Protein Families

Acyl-CoA oxidase family

Tissue Specificity

Present in all tissues tested: heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Most abundant in heart, liver and kidney.

Database Links

HGNC: 120

OMIM: 601641

KEGG: hsa:8309

STRING: 9606.ENSP00000307697

UniGene: Hs.444959

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

PPAR signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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