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| Code | CSB-PA001236ESR2HU |
| Size | US$299 |
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| Have Questions? | Leave a Message or Start an on-line Chat |
| Full Product Name | Rabbit anti-Homo sapiens (Human) ACTL6A Polyclonal antibody | ||||||
| Uniprot No. | O96019 | ||||||
| Target Names | ACTL6A | ||||||
| Alternative Names |
53 kDa BRG1 associated factor A antibody; 53 kDa BRG1-associated factor A antibody; ACL6A_HUMAN antibody; Actin like 6A antibody; Actin like protein 6A antibody; Actin related protein 4 antibody; Actin related protein antibody; Actin related protein Baf53a antibody; Actin-like protein 6A antibody; Actin-related protein Baf53a antibody; ACTL 6 antibody; ACTL 6A antibody; ACTL6 antibody; ACTL6A antibody; Arp4 antibody; ARPN BETA antibody; ArpNbeta antibody; BAF 53A antibody; BAF complex 53 kDa subunit antibody; BAF53 antibody; BAF53A antibody; BRG1 associated factor antibody; BRG1-associated factor 53A antibody; hArpN beta antibody; INO80 complex subunit K antibody; INO80K antibody; MGC5382 antibody
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| Raised in | Rabbit | ||||||
| Species Reactivity | Human, Mouse | ||||||
| Immunogen | Recombinant Human Actin-like protein 6A protein (1-280AA) | ||||||
| Immunogen Species | Homo sapiens (Human) | ||||||
| Conjugate | Non-conjugated | ||||||
| Clonality | Polyclonal | ||||||
| Isotype | IgG | ||||||
| Purification Method | Antigen Affinity Purified | ||||||
| Concentration | It differs from different batches. Please contact us to confirm it. | ||||||
| Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. | ||||||
| Form | Liquid | ||||||
| Tested Applications | ELISA, WB, IHC, ChIP | ||||||
| Recommended Dilution |
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| Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol Native Chromatin Immunoprecipitation(ChIP) Protocol |
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| Troubleshooting and FAQs | Antibody FAQs | ||||||
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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| Function |
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
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| Gene References into Functions |
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| Involvement in disease | ACTL6A mutations have been found in patients with intellectual disability of variable severity, developmental delay, dysmorphic features and digit abnormalities. Additional features may include genitourinary and cardiac defects. The disease phenotype resembles Coffin-Siris syndrome and brachymorphism-onychodysplasia-dysphalangism syndrome. |
| Subcellular Location | Nucleus. |
| Protein Families | Actin family |
| Database Links |
HGNC: 24124 OMIM: 604958 KEGG: hsa:86 STRING: 9606.ENSP00000397552 UniGene: Hs.435326 |
