ADAMDEC1 Antibody

Code CSB-PA049233
Size US$299 How to order?
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA049233(ADAMDEC1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA049233(ADAMDEC1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
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Product Details

Uniprot No. O15204
Target Names ADAMDEC1
Alternative Names A disintegrin and metalloproteinase domain like protein decysin 1 antibody; A disintegrin and metalloproteinase domain-like protein decysin-1 antibody; ADAM DEC1 antibody; ADAM like decysin 1 antibody; ADAM like protein decysin 1 antibody; ADAM-like protein decysin-1 antibody; ADAMDEC 1 antibody; Adamdec1 antibody; ADEC1_HUMAN antibody; Decysin antibody; Disintegrin protease antibody; M12.219 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Fusion protein of Human ADAMDEC1
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method Antigen affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form Liquid
Tested Applications ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
IHC 1:25-1:100
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May play an important role in the control of the immune response and during pregnancy.
Gene References into Functions
  1. Data suggest that activated platelets release ADAMDEC1, which hydrolyzes pro-EGF (epidermal growth factor) to soluble, active HMW-EGF; proteolytic cleavage of pro-EGF first occurs at the C-terminal arginyl residue of the EGF domain; proteolysis is the regulated, rate-limiting step in generating soluble EGF from activated platelets. PMID: 28455445
  2. We hypothesize that these unique features of ADAMDEC1 may have evolved to escape from inhibition by endogenous metalloprotease inhibitors PMID: 25564618
  3. ADAMDEC1 functions as an active metalloprotease. PMID: 23754285
  4. molecular evolution by duplication in a metalloprotease gene cluster on chromosome 8p12 PMID: 12037602
  5. The ADAMDEC 1 haplotype may indicate an underlying mechanism for high FVIII levels in venous thromboembolism. PMID: 18449420
  6. Gene expression profiling performed on tissues obtained from pulmonary sarcoidosis patients identified ADAMDEC1 as a potential pathogenic mediator of lung damage and/or remodeling and may serve as a marker for this disease. PMID: 19218196

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Subcellular Location Secreted.
Tissue Specificity Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the germinal center. Weakly expressed in mon
Database Links

HGNC: 16299

OMIM: 606393

KEGG: hsa:27299

STRING: 9606.ENSP00000256412

UniGene: Hs.521459

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