AHI1 Antibody

Datasheet
Code CSB-PA836642LA01HU
Size US$299
Uniprot No. Q8N157
Image
  • Western Blot
    Positive WB detected in: K562 whole cell lysate, SH-SY5Y whole cell lysate, HL-60 whole cell lysate, U251 whole cell lysate
    All lanes: AHI1 antibody at 1:2000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 138, 121, 71 kDa
    Observed band size: 138 kDa

  • IHC image of CSB-PA836642LA01HU diluted at 1:200 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Human Jouberin protein (1-213AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:200-1:500
Relevance Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1), AHI1
Immunogen Species Homo sapiens (Human)
Research Area Cell Biology
Target Names AHI1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation.
Involvement in disease Joubert syndrome 3 (JBTS3)
Subcellular Location Cytoplasm, cytoskeleton, cilium basal body, Cell junction, adherens junction, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Tissue Specificity Highly expressed in the most primitive normal hematopoietic cells. Expressed in brain, particularly in neurons that give rise to the crossing axons of the corticospinal tract and superior cerebellar peduncles. Expressed in kidney (renal collecting duct ce
Database Links

HGNC: 21575

OMIM: 608629

KEGG: hsa:54806

STRING: 9606.ENSP00000265602

UniGene: Hs.386684

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