AIFM3 Antibody

Code CSB-PA001494GA01HU
Size US$685
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Product Details

Uniprot No. Q96NN9
Target Names AIFM3
Alternative Names AIFL antibody; Aifm3 antibody; AIFM3_HUMAN antibody; Apoptosis inducing factor 3 antibody; Apoptosis inducing factor like antibody; Apoptosis inducing factor like protein antibody; Apoptosis inducing factor; mitochondrion associated antibody; Apoptosis-inducing factor 3 antibody; Apoptosis-inducing factor-like protein antibody; FLJ30473 antibody; FLJ45137 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human AIFM3
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB,IHC
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.
Gene References into Functions
  1. Upregulated expression of AIFM3 is associated with cholangiocarcinoma. PMID: 27473083
  2. The expression of apoptosis-inducing factor was identified in pineal gland and thymus, but it did not change with age. PMID: 22550867
  3. AIFM3 is a direct target of miR-210 in human hepatoma cells. PMID: 22387901
  4. AIFL has 598 amino acids, with a characteristic Rieske domain and a pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). AIFL shares 35% homology with AIF, mainly in the Pyr_redox domain. PMID: 15764604
  5. AIF maintains the transformed state of colon cancer cells through its NADH oxidase activity, by mechanisms that involve complex I function. PMID: 16001080
  6. H. pylori triggers apoptosis in AGS cells via interaction with death receptors in the plasma membrane, leading to the cleavage of procaspase-8, release of cytochrome c and AIF from mitochondria, and activation of subsequent downstream apoptotic events PMID: 19166416

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Subcellular Location Mitochondrion
Protein Families FAD-dependent oxidoreductase family
Tissue Specificity Ubiquitous. Expressed in bone marrow, cerebral cortex, liver, ovary, thymus, thyroid gland and tongue (at protein level).
Database Links

HGNC: 26398

OMIM: 617298

KEGG: hsa:150209

STRING: 9606.ENSP00000382120

UniGene: Hs.723246

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