AIFM3 Antibody

Code CSB-PA000835
Size US$100
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  • Western Blot analysis of HeLa cells using AIFL Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
AIFM3
Alternative Names
AIFL antibody; Aifm3 antibody; AIFM3_HUMAN antibody; Apoptosis inducing factor 3 antibody; Apoptosis inducing factor like antibody; Apoptosis inducing factor like protein antibody; Apoptosis inducing factor; mitochondrion associated antibody; Apoptosis-inducing factor 3 antibody; Apoptosis-inducing factor-like protein antibody; FLJ30473 antibody; FLJ45137 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from the N-terminal region of Human AIFL.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.
Gene References into Functions
  1. Upregulated expression of AIFM3 is associated with cholangiocarcinoma. PMID: 27473083
  2. The expression of apoptosis-inducing factor was identified in pineal gland and thymus, but it did not change with age. PMID: 22550867
  3. AIFM3 is a direct target of miR-210 in human hepatoma cells. PMID: 22387901
  4. AIFL has 598 amino acids, with a characteristic Rieske domain and a pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). AIFL shares 35% homology with AIF, mainly in the Pyr_redox domain. PMID: 15764604
  5. AIF maintains the transformed state of colon cancer cells through its NADH oxidase activity, by mechanisms that involve complex I function. PMID: 16001080
  6. H. pylori triggers apoptosis in AGS cells via interaction with death receptors in the plasma membrane, leading to the cleavage of procaspase-8, release of cytochrome c and AIF from mitochondria, and activation of subsequent downstream apoptotic events PMID: 19166416

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Subcellular Location
Mitochondrion. Note=Does not translocate to the nucleus upon induction of apoptosis.
Protein Families
FAD-dependent oxidoreductase family
Tissue Specificity
Ubiquitous. Expressed in bone marrow, cerebral cortex, liver, ovary, thymus, thyroid gland and tongue (at protein level).
Database Links

HGNC: 26398

OMIM: 617298

KEGG: hsa:150209

STRING: 9606.ENSP00000382120

UniGene: Hs.723246

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