ALKBH7 Antibody

Datasheet

Code	CSB-PA001613GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q9BT30

Target Names

ALKBH7

Alternative Names

ALKBH7 antibody; ABH7 antibody; SPATA11 antibody; UNQ6002/PRO34564 antibody; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7 antibody; mitochondrial antibody; EC 1.14.11.- antibody; Alkylated DNA repair protein alkB homolog 7 antibody; Spermatogenesis cell proliferation-related protein antibody; Spermatogenesis-associated protein 11 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human ALKBH7

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism.

Gene References into Functions

Our results uncovered a SNP of ALKBH7, rs7540, which is associated with prostate cancer disease in a statistically significantly manner in two separate cohorts, and maintained in African American men. PMID: 28231280
ALKBH7 possesses the conserved double-stranded beta-helix fold that coordinates a catalytically active iron by a conserved HX(D/E) em leader Xn em leader H motif. PMID: 25122757
novel role for a AlkB homolog, human ALKBH7, in programmed necrosis, presenting a new target for therapeutic intervention in cancer cells that are resistant to apoptotic cell death PMID: 23666923

Subcellular Location

Mitochondrion matrix.

Protein Families

AlkB family

Tissue Specificity

Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta.

Database Links

HGNC: 21306

OMIM: 613305

KEGG: hsa:84266

STRING: 9606.ENSP00000245812

UniGene: Hs.111099

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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