ALPK2 Antibody

Datasheet

Code	CSB-PA042187
Size	US$297
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Image	Immunohistochemistry analysis of paraffin-embedded human heart tissue, using ALPK2 antibody.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ALPK2 Polyclonal antibody

Uniprot No.

Q86TB3

Target Names

ALPK2

Alternative Names

Alpha-protein kinase 2 antibody; ALPK2 antibody; ALPK2_HUMAN antibody; FLJ34875 antibody; FLJ43253 antibody; Gm549 antibody; HAK antibody; Heart alpha-protein kinase antibody; RGD1564431 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from internal of Human ALPK2.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:50-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling.

Gene References into Functions

Results showed that p.Q1853E variant of ALPK2, which had been accumulating in the Japanese population, induced a metastatic phenotype of colorectal tumors by disrupting ALPK2 function. PMID: 28668886
ALPK2 is crucial for luminal apoptosis and expression of DNA repair-related genes, possibly in the transition of normal colonic crypt to adenoma. PMID: 22641666

Subcellular Location

Basolateral cell membrane.

Protein Families

Protein kinase superfamily, Alpha-type protein kinase family, ALPK subfamily

Tissue Specificity

Expressed in developing cardiac tissue and cardiomyocytes (at protein level).

Database Links

HGNC: 20565

KEGG: hsa:115701

STRING: 9606.ENSP00000354991

UniGene: Hs.628152

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Target Therapy

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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