ALPK2 Antibody

Code CSB-PA042187
Size US$297
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  • Immunohistochemistry analysis of paraffin-embedded human heart tissue, using ALPK2 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ALPK2 Polyclonal antibody
Uniprot No.
Target Names
ALPK2
Alternative Names
Alpha-protein kinase 2 antibody; ALPK2 antibody; ALPK2_HUMAN antibody; FLJ34875 antibody; FLJ43253 antibody; Gm549 antibody; HAK antibody; Heart alpha-protein kinase antibody; RGD1564431 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from internal of Human ALPK2.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:50-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling.
Gene References into Functions
  1. Results showed that p.Q1853E variant of ALPK2, which had been accumulating in the Japanese population, induced a metastatic phenotype of colorectal tumors by disrupting ALPK2 function. PMID: 28668886
  2. ALPK2 is crucial for luminal apoptosis and expression of DNA repair-related genes, possibly in the transition of normal colonic crypt to adenoma. PMID: 22641666
Subcellular Location
Basolateral cell membrane.
Protein Families
Protein kinase superfamily, Alpha-type protein kinase family, ALPK subfamily
Tissue Specificity
Expressed in developing cardiac tissue and cardiomyocytes (at protein level).
Database Links

HGNC: 20565

KEGG: hsa:115701

STRING: 9606.ENSP00000354991

UniGene: Hs.628152

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